Nature Search

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

Tatyana V. Pestova
Sergei I. Borukhov
Christopher U. T. Hellen
Research27 Aug 1998
Nature

Volume: 394, P: 854-859
Phylogenomics and the rise of the angiosperms

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Alexandre R. Zuntini
Tom Carruthers
William J. Baker
ResearchOpen Access24 Apr 2024
Nature

Volume: 629, P: 843-850
Increased frequency of repeat expansion mutations across different populations

Repeat expansion disorders are found in all major global populations, and their frequency is up to three times higher than typically quoted, suggesting underdiagnosis or incomplete penetrance.

Kristina Ibañez
Bharati Jadhav
Arianna Tucci
ResearchOpen Access01 Oct 2024
Nature Medicine

Volume: 30, P: 3357-3368
Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

Implant infection is the most common mode of joint replacement failure with serious complications. Here, the authors report on the in vivo application of a prophylactic coating technology that can incorporate a range of antibiotics and be applied in the operating room prior to implantation.

Weixian Xi
Vishal Hegde
Tatiana Segura
ResearchOpen Access16 Sept 2021
Nature Communications

Volume: 12, P: 1-15
DNA sequence-dependent formation of heterochromatin nanodomains

The ability to predict epigenetic regulation is an important challenge in biology. Here the authors describe heterochromatin nanodomains (HNDs) and compare four different types of H3K9me2/3-marked HNDs in mouse embryonic stem cells. They further develop a computational framework to predict genome-wide HND maps from DNA sequence and protein concentrations, at single-nucleotide resolution.

Graeme J. Thorn
Christopher T. Clarkson
Vladimir B. Teif
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-13
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s disease, multiple sclerosis and autism

Christopher Exley
Elizabeth Clarkson
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-7
Massive introgression drives species radiation at the range limit of Anopheles gambiae

José L. Vicente
Christopher S. Clarkson
João Pinto
ResearchOpen Access18 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

Bmal1 is a key transcription factor that controls rhythmicity of diverse biological functions. Here, Pan et al. show that Bmal1 deficiency in mice increases lipoprotein secretion and reduces cholesterol excretion to bile, and decipher the molecular mechanisms underlying hyperlipidaemia and atherosclerosis promoted by the lack of Bmal1.

Xiaoyue Pan
Christopher A. Bradfield
M. Mahmood Hussain
ResearchOpen Access10 Oct 2016
Nature Communications

Volume: 7, P: 1-15
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high confidence, loci associated with each phenotype.

Aysu Okbay
Bart M L Baselmans
David Cesarini
Research18 Apr 2016
Nature Genetics

Volume: 48, P: 624-633
Copper-zirconia interfaces in UiO-66 enable selective catalytic hydrogenation of CO₂ to methanol

Molecular interactions with both oxides and metals are essential for heterogenous catalysis, leading to remarkable impacts on activity. Here the authors show that a direct link between Cu and ZrO2 in a metal organic framework is required to hydrogenate CO2 to methanol.

Yifeng Zhu
Jian Zheng
Johannes A. Lercher
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

Paul A Lyons
James E Peters
Kenneth G. C. Smith
ResearchOpen Access12 Nov 2019
Nature Communications

Volume: 10, P: 1-13
The joining of ribosomal subunits in eukaryotes requires eIF5B

Tatyana V. Pestova
Ivan B. Lomakin
Christopher U. T. Hellen
Research20 Jan 2000
Nature

Volume: 403, P: 332-335
Cloning and Amplification of the Gene Encoding an Extracellular β-Glucosidase from Trichoderma reesei: Evidence for Improved Rates of Saccharification of Cellulosic Substrates

Christopher C. Barnett
Randy M. Berka
Tim Fowler
Research01 Jun 1991
Bio/Technology

Volume: 9, P: 562-567
Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1

Carolyn Allain Breckel
Zane M. Johnson
Mark Hochstrasser
ResearchOpen Access24 Jan 2024
Scientific Reports

Volume: 14, P: 1-16
Specific changes in rasGAP-associated 62 kilodalton protein during integrin mediated cell-substrate interaction

Sreenath V Sharma
Artashes Boyajian
Hirofumi Nakano
Research05 Jun 1997
Oncogene

Volume: 14, P: 2641-2649
Small molecule derails translation initiation

Eukaryotic initiation factor (eIF) 4A plays an essential role in translation initiation on most eukaryotic mRNAs by unwinding their secondary structure to permit ribosomal attachment and scanning. The natural product hippuristanol selectively inhibited eIF4A- and eIF4A-dependent modes of translation initiation.

Tatyana V Pestova
Christopher U T Hellen
News & Views01 Apr 2006
Nature Chemical Biology

Volume: 2, P: 176-177
Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer

Deepak Singhal
Christopher N. Hahn
Devendra K. Hiwase
Research13 Apr 2021
Leukemia

Volume: 35, P: 3245-3256
Emerging applications of stimuli-responsive polymer materials

Stimuli-responsive polymers can be engineered, in both film and colloid forms, to respond to a variety of inputs, from temperature to pH. The inherent flexibility in their structure and responses result in materials that lend themselves to applications ranging from drug delivery to sensing. Recent advances and future challenges in this direction are reviewed.

Martien A. Cohen Stuart
Wilhelm T. S. Huck
Sergiy Minko
Reviews22 Jan 2010
Nature Materials

Volume: 9, P: 101-113
Translation, interrupted

A recent study shows that the Drosophila melanogaster proapoptotic protein Reaper inhibits protein synthesis by direct binding to 40S ribosomal subunits, which affects recognition of initiation codons and ribosomal subunit joining.

Tatyana V Pestova
Christopher U T Hellen
News & Views01 Feb 2006
Nature Structural & Molecular Biology

Volume: 13, P: 98-99
Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53

Anna Kasprzyk-Pawelec
Mingjun Tan
Maria Laura Avantaggiati
ResearchOpen Access29 Dec 2024
Cell Death & Differentiation

Volume: 32, P: 818-836
MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Patrick McCoy
Stefano Mangiola
Christopher M. Hovens
Research09 Jun 2021
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 1167-1180
Mismatch repair deficiency as a prognostic factor in mucinous colorectal cancer

Juliana Andrici
Mahtab Farzin
Anthony J Gill
Research15 Jan 2016
Modern Pathology

Volume: 29, P: 266-274
Comparative meta-omics for identifying pathogens associated with prosthetic joint infection

Karan Goswami
Alexander J. Shope
Regina Lamendella
ResearchOpen Access09 Dec 2021
Scientific Reports

Volume: 11, P: 1-12
NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas—a study of 4569 cases

Angela Chou
Tamara Fraser
Anthony J. Gill
Research02 Dec 2019
Modern Pathology

Volume: 33, P: 924-932
Evading the host response: Staphylococcus “hiding” in cortical bone canalicular system causes increased bacterial burden

Stephen D. Zoller
Vishal Hegde
Nicholas M. Bernthal
ResearchOpen Access10 Dec 2020
Bone Research

Volume: 8, P: 1-11
A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation

Brandon M. Trainor
Arnab Ghosh
Natalia Shcherbik
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-18
A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance

Nikhil Sapre
Geoff Macintyre
Christopher M Hovens
ResearchOpen Access26 Jan 2016
British Journal of Cancer

Volume: 114, P: 454-462

Search

Mapping the human genetic architecture of COVID-19

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Whole-genome sequencing reveals host factors underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons

Phylogenomics and the rise of the angiosperms

Increased frequency of repeat expansion mutations across different populations

Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge

DNA sequence-dependent formation of heterochromatin nanodomains

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s disease, multiple sclerosis and autism

Massive introgression drives species radiation at the range limit of Anopheles gambiae

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Copper-zirconia interfaces in UiO-66 enable selective catalytic hydrogenation of CO₂ to methanol

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

The joining of ribosomal subunits in eukaryotes requires eIF5B

Cloning and Amplification of the Gene Encoding an Extracellular β-Glucosidase from Trichoderma reesei: Evidence for Improved Rates of Saccharification of Cellulosic Substrates

Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1

Specific changes in rasGAP-associated 62 kilodalton protein during integrin mediated cell-substrate interaction

Small molecule derails translation initiation

Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer

Emerging applications of stimuli-responsive polymer materials

Translation, interrupted

Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53

MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer

Mismatch repair deficiency as a prognostic factor in mucinous colorectal cancer

Comparative meta-omics for identifying pathogens associated with prosthetic joint infection

NTRK gene rearrangements are highly enriched in MLH1/PMS2 deficient, BRAF wild-type colorectal carcinomas—a study of 4569 cases

Evading the host response: Staphylococcus “hiding” in cortical bone canalicular system causes increased bacterial burden

A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation

A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance

Search

Quick links

Search

Filter By:

Search

Quick links