Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Christopher W. am Ende Clear advanced filters

  • Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a driver of ocular toxicity.

    • Andrea M. Zuhl
    • Charles E. Nolan
    • Douglas S. Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Carbene chemistry is used to introduce difluoromethyl groups labelled with fluorine-18 into compounds for positron emission tomography imaging, using a reagent designed for high molar activity and versatility.

    • Jeroen B. I. Sap
    • Claudio F. Meyer
    • Véronique Gouverneur
    Research
    Nature
    Volume: 606, P: 102-108

  • GPAT1 is a mitochondrial outer membrane protein that catalyzes the first step of glycerolipid biosynthesis. Cryo-EM structures and functional studies of human GPAT1 uncover the molecular architecture and mechanism of this important acyltransferase.

    • Zachary Lee Johnson
    • Mark Ammirati
    • Huixian Wu
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 22-30

  • A deep chemical proteomic investigation of diverse aminophilic electrophiles has identified ligandable lysines across a wide range of human proteins. The proteins cover different functional and structural classes, and the aminophilic electrophiles include compounds that disrupt protein–protein and protein–RNA interactions. This dataset provides a proteome-wide atlas of lysine-reactive chemistry.

    • Mikail E. Abbasov
    • Madeline E. Kavanagh
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 13, P: 1081-1092

  • Lysosomal integral membrane protein-2 (LIMP-2) is a glucocerebrosidase receptor, which is linked to kidney failure and other diseases. Here the authors show that LIMP-2 is also a phospholipid receptor and present the lipid-bound structure of the LIMP-2 luminal domain dimer and discuss its lipid trafficking mechanism.

    • Karen S. Conrad
    • Ting-Wen Cheng
    • Michael D. Ehlers
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • The underlying mechanisms and optimal conditions that drive biorthogonal reactions and the utility of these for applications in medicinal chemistry and protein synthesis to polymers and materials science are described in this Primer. Current reproducibility standards and how current reaction limitations are driving new research efforts are also discussed.

    • Samuel L. Scinto
    • Didier A. Bilodeau
    • Joseph M. Fox
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-23