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Showing 1–3 of 3 results
Advanced filters: Author: Chrysa Nikopoulou Clear advanced filters

  • PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.

    • Pinar Ayata
    • Jessica M. Crowley
    • Anne Schaefer
    ResearchOpen Access
    Nature
    Volume: 648, P: 157-165

  • Aged mesenchymal stem cells exhibit decreased osteogenesis. Pouikli et al. link impaired MSC differentiation to histone hypoacetylation caused by lower mitochondrial acetyl-CoA export due to enhanced lysosomal degradation of the citrate carrier Slc25a1. Restoring histone acetylation to youthful levels rescues osteogenesis.

    • Andromachi Pouikli
    • Swati Parekh
    • Peter Tessarz
    ResearchOpen Access
    Nature Aging
    Volume: 1, P: 810-825