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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Genome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.

Jacob M. Keaton
Zoha Kamali
Helen R. Warren
ResearchOpen Access30 Apr 2024
Nature Genetics

Volume: 56, P: 778-791
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

Bernard Keavney, Judith Goodship and colleagues report a genome-wide association study of congenital heart disease and identify a region on chromosome 4p16 associated with risk of atrial septal defect.

Heather J Cordell
Jamie Bentham
Bernard D Keavney
Research26 May 2013
Nature Genetics

Volume: 45, P: 822-824
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Amendments and Corrections14 Nov 2018
Nature Genetics

Volume: 50, P: 1755
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.

Helen R Warren
Evangelos Evangelou
Paul Elliott
Research30 Jan 2017
Nature Genetics

Volume: 49, P: 403-415

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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

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