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Targeting COL6A3-C5 with nigericin suppresses endotrophin formation and enhances insulin sensitivity in obesity

Chu-Sook Kim
Woobeen Jo
Jiyoung Park
ResearchOpen Access05 Mar 2026
Experimental & Molecular Medicine

Volume: 58, P: 768-781
Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia

Despite hyperglycemia has been associated to breast cancer, the underlying mechanisms are not completely understood. Here, the authors show that epigenetic regulation of Nrg1 gene during hyperglycemia promotes breast cancer development.

Changhu Lee
Min Kim
Jiyoung Park
ResearchOpen Access27 Jan 2023
Nature Communications

Volume: 14, P: 1-15

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Targeting COL6A3-C5 with nigericin suppresses endotrophin formation and enhances insulin sensitivity in obesity

Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia

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