Ceramide metabolism has garnered increasing attention in liver diseases, but its role in cholestatic liver injury remains unclear. Here the authors show that targeting ACER3, a ceramidase upregulated in cholestatic liver, alleviates liver injury in mice by enhancing bile acid sulfation to reduce bile acid overload through unsaturated ceramide-activated LXRβ signaling.
- Leyi Liao
- Ziying Liu
- Kai Wang
