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Showing 1–3 of 3 results
Advanced filters: Author: Chuanteng Ma Clear advanced filters

  • Prenylation modifications of natural products play essential roles in chemical diversity and bioactivities, but imidazole modification prenyltransferases are not well investigated. Here, the authors discover and characterize a dimethylallyl tryptophan synthase family prenyltransferase, AuraA, that catalyzes the rare dimethylallylation on the imidazole moiety in the biosynthesis of aurantiamine.

    • Wenxue Wang
    • Peng Wang
    • Dehai Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Eremophilanes represent a prominent class of sesquiterpenoid natural products. Here, the authors report a series of eremophilane derivatives, including the aromatic structures of farfugin A and aza-janthinellin A, and the non-aromatic structure of phomenonol A, and show that the formation of farfugin A and aza-janthinellin A involves ring arrangement and aromatization process initiated by heteroatom nucleophilic addition and mediated by a FAD-dependent monooxygenase.

    • Hengyi Xu
    • Xianyan Zhang
    • Guojian Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Cytochalasans are a large family of fungal polyketide-nonribosomal peptide hybrid natural products that exhibit important pharmaceutical activities, but the mechanism of conversion of the monocytochalasans to the polycyclic, fused analogues is unclear. Here the authors reconstitute the core backbone of the cytochalasin family and describe an oxidase that catalyzes an unusual double-bond isomerization reaction.

    • Jin-Mei Zhang
    • Xuan Liu
    • Yi Zou
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10