The term 'chronic allograft nephropathy' describes a clinical syndrome of proteinuria, hypertension and declining renal function, that is a major cause of late graft loss in renal transplant recipients. In this concise Review, authors from Korea discuss the contribution of immunological and non-immunological factors to the pathogenesis of chronic allograft nephropathy. In the absence of a definitive treatment protocol for the condition, they offer recommendations to minimize some of these underlying risk factors.
