Conventional photosensitizers mediate type II photodynamic therapy (PDT) via energy transfer, which is less effective in hypoxic tumors. Here, the authors combine photoredox chemistry with the hyperporphyrin effect in an iminium-linked covalent organic framework to enable efficient type I PDT under 725 nm irradiation in normoxic and hypoxic environments.
- Zhibei Zhou
- Yuxuan Xiong
- Wenbin Lin
