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Showing 1–3 of 3 results
Advanced filters: Author: Chun-Shik Shin Clear advanced filters

  • The factors that limit the nutrient flexibility of cells remain largely unknown. Here, the authors identify the glutamate/cysteine antiporter xCT in a genetic screen for glucose dependency and show it determines the ability of cells to survive under conditions of low glucose by limiting the utilization of glutamine.

    • Chun-Shik Shin
    • Prashant Mishra
    • David C. Chan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.

    • Chun-Shik Shin
    • Shuxia Meng
    • David C. Chan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10