Nature Search

A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability

Our understanding of the function and molecular origin of ultra-long action potentials—which can last a few seconds to several minutes—is extremely limited. Here, Cang et al. show that ultra-long action potentials are generated by a novel type of voltage-gated sodium channel.

Chunlei Cang
Kimberly Aranda
Dejian Ren
Research26 Sept 2014
Nature Communications

Volume: 5, P: 1-9
Author Correction: A growth-factor-activated lysosomal K⁺ channel regulates Parkinson’s pathology

Jinhong Wie
Zhenjiang Liu
Dejian Ren
Amendments and Corrections31 Mar 2021
Nature

Volume: 592, P: E10
Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

Carnosine is a mobile buffering metabolite. Here the authors link carnosine accumulation, hypoxia and intracellular pH homeostasis in cancer cells as a mechanism of tumor immune evasion via NFX1 degradation and galectin-9 activity.

Ronghui Yan
Pinggen Zhang
Ping Gao
Research04 Jan 2024
Nature Immunology

Volume: 25, P: 483-495
Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation

The anion channel SLAC1 controls stomatal closure upon phosphoactivation. Here via structural analysis and electrophysiology, the authors propose an inhibition-release model where phosphorylation causes dissociation of a cytosolic plug from the SLAC1 transmembrane domains to induce conformational change in the pore-forming helices.

Yawen Li
Yinan Ding
Linfeng Sun
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-9
Metabolomic profiling of single enlarged lysosomes

Single-lysosome mass spectrometry (SLMS) integrates lysosomal patch-clamp recording and induced nanoESI/MS for concurrent metabolic and electrophysiological profiling of individual enlarged lysosomes.

Hongying Zhu
Qianqian Li
Wei Xiong
Research14 Jun 2021
Nature Methods

Volume: 18, P: 788-798
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

Chen, Cang and colleagues describe how to characterize intracellular ion channels using a manual patch-clamp technique on enlarged organelles such as endolysosomes.

Cheng-Chang Chen
Chunlei Cang
Christian Grimm
Protocols20 Jul 2017
Nature Protocols

Volume: 12, P: 1639-1658
A growth-factor-activated lysosomal K⁺ channel regulates Parkinson’s pathology

The identification of a lysosomal K⁺ channel complex—comprising AKT and the pore-forming TMEM175—provides insights into the mechanisms through which variants of the pore-forming protein affect the development of Parkinson’s disease.

Jinhong Wie
Zhenjiang Liu
Dejian Ren
Research27 Jan 2021
Nature

Volume: 591, P: 431-437
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

The X-ray crystal structure of a two-pore channel from Arabidopsis thaliana reveals the structure and the mechanism of voltage gating of this class of ubiquitous cation-selective ion channels.

Jiangtao Guo
Weizhong Zeng
Youxing Jiang
Research21 Dec 2015
Nature

Volume: 531, P: 196-201
The voltage-gated sodium channel TPC1 confers endolysosomal excitability

Endosomes and lysosomes are electrically excitable, and this is conferred by a new family of atypical voltage-gated sodium channels, lysoNa_Vs, formed by TPC1, which has similar mechanisms for gating as canonical voltage-gated channels and is sensitive to pH, appropriate for its localization in acidic compartments.

Chunlei Cang
Biruk Bekele
Dejian Ren
Research28 Apr 2014
Nature Chemical Biology

Volume: 10, P: 463-469
The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

The lysosomal potassium channel TMEM175 has a tetrameric structure unlike that of the canonical potassium channels, with an hourglass-shaped pore in which isoleucine residues have a key role in channel selectivity.

Changkeun Lee
Jiangtao Guo
Youxing Jiang
Research19 Jul 2017
Nature

Volume: 547, P: 472-475
Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis

Chunhong Fan
Haotian Wu
Chunlei Cang
ResearchOpen Access27 May 2024
Cell Death Discovery

Volume: 10, P: 1-12

Search

A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability

Author Correction: A growth-factor-activated lysosomal K⁺ channel regulates Parkinson’s pathology

Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion

Structure of the Arabidopsis guard cell anion channel SLAC1 suggests activation mechanism by phosphorylation

Metabolomic profiling of single enlarged lysosomes

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

A growth-factor-activated lysosomal K⁺ channel regulates Parkinson’s pathology

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis

Search

Quick links

Search

Filter By:

Search

Quick links