Nature Search

Structural insight into IscB’s RNA-lid-based inactivation mechanism

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

Feizuo Wang
Ruochen Guo
Chunyi Hu
ResearchOpen Access25 Mar 2026
Nature Structural & Molecular Biology

P: 1-12
Enabling low-temperature aqueous zinc/copper-sulfur hybrid batteries through electrolyte design

Aqueous batteries suffer from poor performance in extreme cold. Here, authors design an electrolyte enabling a high-energy zinc-sulfur battery that operates at –50 °C, offering a promising solution for low-temperature energy storage.

Haichuan Zhou
Linyu Hu
Zifeng Lin
ResearchOpen Access25 Feb 2026
Nature Communications

Volume: 17, P: 1-12
GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Bingsong Huang
Mingpeng Jin
Chunlong Zhong
Research13 Jan 2026
Nature Chemical Biology

Volume: 22, P: 634-648
Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Chunlong Xu
Yingsi Zhou
Hui Yang
Amendments and Corrections02 Jan 2022
Nature Methods

Volume: 19, P: 255
Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

This work describes the identification of Cas13 proteins from two families by mining public metagenomic data. The newly identified Cas13X.1 shows efficient target knockdown and can be used to degrade SARS-CoV-2 and H1N1 genomes. In addition, the truncated Cas13X.1 offers an advantage in generating mini-RNA base editors.

Chunlong Xu
Yingsi Zhou
Hui Yang
Research03 May 2021
Nature Methods

Volume: 18, P: 499-506
Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

Duchenne muscular dystrophy (DMD) results from mutations in the DMD. Here the authors report using adenine base editing of exon splice sites to restore dystrophin expression and muscle function in a humanized mouse model of DMD with exon 50 and 51 of mouse DMD gene replaced with human exon 50.

Jiajia Lin
Ming Jin
Guoling Li
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-12
N⁷-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Deregulation of METTL1-mediated N7- methylguanosine tRNA modification can promote oncogenesis. Here, the authors report that this modification regulates the translation of proteins in both the mTOR and negative regulators of autophagy pathways, resulting in the progression of esophageal squamous cell carcinoma.

Hui Han
Chunlong Yang
Shuibin Lin
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-15
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

Several engineered Cas13 variants achieve targeted RNA degradation with minimal collateral effects.

Huawei Tong
Jia Huang
Hui Yang
Research11 Aug 2022
Nature Biotechnology

Volume: 41, P: 108-119
An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA for degradation and reducing protein levels in the brain of humanized MECP2-transgenic mice and nonhuman primates.

Dong Yang
Xiaoqing Wu
Hui Yang
Research12 Dec 2024
Nature Neuroscience

Volume: 28, P: 72-83
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

A base editor is engineered for A-to-T and A-to-C transversion editing.

Huawei Tong
Xuchen Wang
Hui Yang
Research09 Jan 2023
Nature Biotechnology

Volume: 41, P: 1080-1084
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Miniature gene editing tools are highly desired for efficient in vivo delivery and disease treatment. Here, the authors reported engineering hypercompact TnpB-ωRNA for robust gene editing with minimal off-target effect in cultured cells and use it to rescue fatal genetic liver disease in a tyrosinaemia mouse model.

Zhifang Li
Ruochen Guo
Chunlong Xu
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Self-focusing high-frequency ultrasonic transducers for non-destructive testing applications

Jianxin Zhao
Jialin Hao
Yintang Yang
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
N⁶-methyladenosine (m⁶A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation

RNA modifications have emerged as important regulators of RNA function. In this study, Peng, Chen, Wei and Guo et al. show that the 18S rRNA N⁶-methyladenosine methyltransferase complex METTL5–TRMT112 regulates hepatic lipid metabolism and contributes to hepatocellular carcinoma.

Hao Peng
Binbin Chen
Shuibin Lin
Research23 Aug 2022
Nature Metabolism

Volume: 4, P: 1041-1054
A seamlessly integrated device of micro-supercapacitor and wireless charging with ultrahigh energy density and capacitance

Miniaturized energy storage devices integrated with wireless charging bring opportunities for next generation electronics. Here, authors report seamlessly integrated wireless charging micro-supercapacitors with high energy density capable of driving a model electrical car.

Chang Gao
Jiancheng Huang
Liangti Qu
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-10
Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

De novo genome assemblies of 12 species from Aurantioideae and pangenome analyses provide insights into the origin and evolution of the orange subfamily and the genetic basis of flavor in citrus fruits.

Yue Huang
Jiaxian He
Qiang Xu
Research02 Oct 2023
Nature Genetics

Volume: 55, P: 1964-1975
Diagnostic classification of coronavirus disease 2019 (COVID-19) and other pneumonias using radiomics features in CT chest images

Ning Yang
Faming Liu
Guihua Jiang
ResearchOpen Access09 Sept 2021
Scientific Reports

Volume: 11, P: 1-7
Enabling fast-charging selenium-based aqueous batteries via conversion reaction with copper ions

Aqueous battery Se-based cathodes are based on a two-electron transfer electrochemical reaction and generally show inadequate rate capability behaviour. Here, the authors propose a four-electron Se chemistry with copper ions as charge carriers to enable fast-charging battery cycling.

Chunlong Dai
Linyu Hu
Liangti Qu
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-10
The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases

Haixiu Yang
Desi Shang
Xia Li
ResearchOpen Access27 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

CRISPR screens identify JNK–JUN family genes as repressors of definitive endoderm differentiation in human pluripotent stem cells. JUN co-occupies stem cell enhancers with OCT4, NANOG, SMAD2 and SMAD3 and inhibits the exit from pluripotency.

Qing V. Li
Gary Dixon
Danwei Huangfu
Research20 May 2019
Nature Genetics

Volume: 51, P: 999-1010
Graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion

Xu Li
Xinlong Wang
Yang Li
ResearchOpen Access20 May 2025
Scientific Reports

Volume: 15, P: 1-19
Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Peroxidase mimics are currently being investigated as catalysts for lignin depolymerisation. In this article, the authors investigate a class of self-assembled and highly stable peptoid/hemin nanomaterials as peroxidase mimics that are highly stable and tuneable for the depolymerisation of a biorefinery lignin.

Tengyue Jian
Yicheng Zhou
Chun-Long Chen
ResearchOpen Access31 May 2022
Nature Communications

Volume: 13, P: 1-13
Physiological and psychological symptom management based on electronic patient-reported outcomes: the TD-WELLBEING randomized clinical trial

Pengyu Jing
Ying Liang
Zhongping Gu
ResearchOpen Access07 Aug 2025
British Journal of Cancer

Volume: 133, P: 937-944
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo

Guixiang Yang
Zixiang Yan
Kailun Fang
Research01 Feb 2023
Gene Therapy

Volume: 30, P: 801-806
Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids

The application potential of organic nanotubes is currently limited by their lack of designable or dynamic properties. Here, Chen et al. use sequence-defined peptoids to assemble a new family of pH-responsive stiff nanotubes whose dimensions, components and functions can be easily tailored.

Haibao Jin
Yan-Huai Ding
Chun-Long Chen
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-11
Deciphering transcriptomic determinants of the divergent link between PD-L1 and immunotherapy efficacy

Anlin Li
Linfeng Luo
Shaodong Hong
ResearchOpen Access11 Sept 2023
npj Precision Oncology

Volume: 7, P: 1-13
Diagnostic identification of chronic insomnia using ALFF and FC features of resting-state functional MRI and logistic regression approach

Ning Yang
Shuyi Yuan
Xiaofen Ma
ResearchOpen Access09 Jan 2023
Scientific Reports

Volume: 13, P: 1-9
METTL1/WDR4-mediated tRNA m⁷G modification and mRNA translation control promote oncogenesis and doxorubicin resistance

Zhaoyu Wang
Peng Yu
Shuibin Lin
Research25 Apr 2023
Oncogene

Volume: 42, P: 1900-1912
Active acoustic field modulation of ultrasonic transducers with flexible composites

The development of technologies to manipulate acoustic waves relies on acoustic lenses and ultrasonic arrays, but it is limited by low transmission efficiencies or bulky setups. The authors propose a flexible and efficient piezoelectric ultrasonic transducer that generates intricate ultrasound wave patterns and deviate from conventional approaches.

Chenxue Hou
Zhaoxi Li
Yintang Yang
ResearchOpen Access15 Sept 2023
Communications Physics

Volume: 6, P: 1-11
Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

Yinghui Wei
Chunlong Xu
Meiling Zhang
CorrespondenceOpen Access01 Feb 2022
Cell Discovery

Volume: 8, P: 1-4
In vivo treatment of tyrosinaemia with hypercompact Cas12f1

Ruochen Guo
Zhifang Li
Chunlong Xu
CorrespondenceOpen Access18 Jul 2023
Cell Discovery

Volume: 9, P: 1-4
ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

Junwei Han
Xinrui Shi
Xia Li
ResearchOpen Access12 Aug 2015
Scientific Reports

Volume: 5, P: 1-15
LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Junwei Han
Siyao Liu
Xia Li
ResearchOpen Access20 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network

Qianlan Yao
Yanjun Xu
Xia Li
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

Yinghui Wei
Zhifang Li
Erwei Zuo
CorrespondenceOpen Access18 Mar 2022
Cell Discovery

Volume: 8, P: 1-4

Search

Structural insight into IscB’s RNA-lid-based inactivation mechanism

Enabling low-temperature aqueous zinc/copper-sulfur hybrid batteries through electrolyte design

GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression

Author Correction: Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Adenine base editing-mediated exon skipping restores dystrophin in humanized Duchenne mouse model

N⁷-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects

An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model

Self-focusing high-frequency ultrasonic transducers for non-destructive testing applications

N⁶-methyladenosine (m⁶A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation

A seamlessly integrated device of micro-supercapacitor and wireless charging with ultrahigh energy density and capacitance

Pangenome analysis provides insight into the evolution of the orange subfamily and a key gene for citric acid accumulation in citrus fruits

Diagnostic classification of coronavirus disease 2019 (COVID-19) and other pneumonias using radiomics features in CT chest images

Enabling fast-charging selenium-based aqueous batteries via conversion reaction with copper ions

The LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

Graph-enhanced implicit aspect-level sentiment analysis based on multi-prompt fusion

Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Physiological and psychological symptom management based on electronic patient-reported outcomes: the TD-WELLBEING randomized clinical trial

Ptbp1 knockdown failed to induce astrocytes to neurons in vivo

Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids

Deciphering transcriptomic determinants of the divergent link between PD-L1 and immunotherapy efficacy

Diagnostic identification of chronic insomnia using ALFF and FC features of resting-state functional MRI and logistic regression approach

METTL1/WDR4-mediated tRNA m⁷G modification and mRNA translation control promote oncogenesis and doxorubicin resistance

Active acoustic field modulation of ultrasonic transducers with flexible composites

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE

In vivo treatment of tyrosinaemia with hypercompact Cas12f1

ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis

LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method

Global Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network

Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

Search

Quick links

Search

Filter By:

Search

Quick links