Nature Search

Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression

Activation of genes depends on transcription factors and chromatin remodelers. Here, the authors show ARID1A organizes these components through phase separation, co-condensing with specific transcription factors to maintain chromatin accessibility and drive gene expression.

Xifu Ye
Lin Xu
Yi Lu
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Glecirasib in KRAS^G12C-mutated nonsmall-cell lung cancer: a phase 2b trial

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Yuankai Shi
Jian Fang
Zhiyue Rao
Research06 Jan 2025
Nature Medicine

Volume: 31, P: 894-900
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes

Duodenal cancer (DC) has complex subtypes and undergoes complicated morphological changes throughout progression, so understanding the molecular basis is crucial. Here, the authors perform a proteogenomics analysis of 156 DCs, revealing molecular subtypes as well as the roles of smoking, AARS1 and PARP1.

Lingling Li
Dongxian Jiang
Chen Ding
ResearchOpen Access29 Mar 2023
Nature Communications

Volume: 14, P: 1-24
Large-scale water collection of bioinspired cavity-microfibers

Spider-silk-mimicking microfibers often suffer from low efficiency and durability in water collection. Here, the authors fabricate robust microfibers with spindle cavity-knots and different topological fiber-networks with improved water-collecting performance

Ye Tian
Pingan Zhu
Liqiu Wang
ResearchOpen Access20 Oct 2017
Nature Communications

Volume: 8, P: 1-9
Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice

ERα^vlVMH neurons mediate the inhibitory role of 17β-oestradiol on prolactin production, and this inhibition is lifted in lactating mice to promote lactation-associated metabolic adaptations.

Meng Yu
Bing Feng
Chunmei Wang
Research10 Apr 2025
Nature Metabolism

Volume: 7, P: 759-777
Integrative proteogenomic characterization of early esophageal cancer

The progression of oesophageal squamous cell carcinoma (ESCC) from early to advanced stages requires comprehensive molecular characterisation. Here, the authors perform a proteogenomics analysis of ESCC patient samples across nine histopathological stages and three phases, identifying key alterations and paths for progression.

Lingling Li
Dongxian Jiang
Chen Ding
ResearchOpen Access25 Mar 2023
Nature Communications

Volume: 14, P: 1-28
Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

The protective role of MAIT cells in the HFRS disease and the ER stress related mechanisms behind MAIT cell pyroptosis during HTNV infection.

Yusi Zhang
He Liu
Yun Zhang
ResearchOpen Access01 Apr 2025
Communications Biology

Volume: 8, P: 1-13
Revealing the light-regulated circadian rhythm in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus

Preferential differences in the compound eye versus ocelli-like light-sensing pathways underlie the distinct diurnal activity of Aedes albopictus and the nocturnal activity of Culex quinquefasciatus.

Hongkai Liu
Ling Kong
Xiao-Guang Chen
ResearchOpen Access09 Dec 2025
Communications Biology

Volume: 9, P: 1-19
Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance

Glucose-sensing neurons are found in the ventromedial hypothalamic nucleus (VMH). Here the authors identify the role of estrogen receptor-α expressing neurons in the ventrolateral subdivision of the VMH in sensing hypoglycemia.

Yanlin He
Pingwen Xu
Yong Xu
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-13
Neural signals gradually shift towards inferior frontal gyrus and long-term effects following facial imitation-based social learning

Qi Liu
Siyu Zhu
Weihua Zhao
ResearchOpen Access18 Nov 2025
npj Science of Learning

Volume: 10, P: 1-14
Asprosin is a centrally acting orexigenic hormone

Asprosin, a recently identified secreted hormone from adipose tissue, acts centrally to promote food intake.

Clemens Duerrschmid
Yanlin He
Atul R Chopra
Research06 Nov 2017
Nature Medicine

Volume: 23, P: 1444-1453
Relationship between mean platelet volume and metabolic syndrome in Chinese patients

Fengxiao Zhao
Ziyu Yan
Wan Zhang
ResearchOpen Access01 Oct 2018
Scientific Reports

Volume: 8, P: 1-6
Inhibitor of growth 3 induces cell death by regulating cell proliferation, apoptosis and cell cycle arrest by blocking the PI3K/AKT pathway

Song Zhao
Long Wang
Xianzhi Meng
Research01 Jun 2018
Cancer Gene Therapy

Volume: 25, P: 240-247
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Development of a new single-cell gene knockout technique shows how new neurons are selected for survival depending on their synaptic input. This provides a possible mechanism for the building of new neuronal circuits during learning and memory.

Ayumu Tashiro
Vladislav M. Sandler
Fred H. Gage
Research13 Aug 2006
Nature

Volume: 442, P: 929-933
Prospective prenatal cell-free DNA screening for genetic conditions of heterogenous etiologies

In a large prospective cohort of 1,090 pregnant women with a high risk of fetal genetic diseases, a cell-free DNA screening identified cases of aneuploidies, microdeletions and monogenic variants with high accuracy in concordance to standard diagnostic tests

Jinglan Zhang
Yanting Wu
Hefeng Huang
Research22 Jan 2024
Nature Medicine

Volume: 30, P: 470-479
Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma

Liang Liu
Rui Wang
Yuhui Yuan
Research15 Jul 2025
Oncogene

Volume: 44, P: 3333-3349
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Obesity induces hypoxia and upregulation of HIF-2α in the gastrointestinal tract, resulting in excess ceramide production and exacerbation of NAFLD.

Cen Xie
Tomoki Yagai
Frank J Gonzalez
Research09 Oct 2017
Nature Medicine

Volume: 23, P: 1298-1308
Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ₁, δ₂, and ε, and evaluate their antimicrobial activity, identifying albomycin δ₂ as a strong agent against S. pneumoniae and S. aureus infections.

Zihua Lin
Xiaobo Xu
Yun He
ResearchOpen Access04 Sept 2018
Nature Communications

Volume: 9, P: 1-8
The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes

Jing Guo
Fengming Huang
Chengyu Jiang
ResearchOpen Access01 Jun 2015
Scientific Reports

Volume: 5, P: 1-10
The prognostic and immune significance of SLAMF9 in pan-cancer and validation of its role in colorectal cancer

Chunmei Zhao
Xingjia Zhu
Xudong Wang
ResearchOpen Access02 Aug 2024
Scientific Reports

Volume: 14, P: 1-14
Metabolic characterization of hypertrophic cardiomyopathy in human heart

Wang et al. analyze the metabolome and lipidome of heart and plasma samples from patients with HCM and healthy individuals and identify panels of metabolites that can be used as diagnostic biomarkers of HCM or predictors of HCM patient survival; patients are stratified into three groups with distinct cardiac function and survival and identify metabolic pathways that are greatly affected in patients with HCM, suggesting that targeting the pentose phosphate pathway and oxidative stress may represent effective ways to treat HCM.

Wenmin Wang
Jizheng Wang
Zeping Hu
Research09 May 2022
Nature Cardiovascular Research

Volume: 1, P: 445-461
Aridity-driven shift in biodiversity–soil multifunctionality relationships

Biodiversity-ecosystem functioning relationships may vary with climate. Here, the authors study relationships of plant and soil microbial diversity with soil nutrient multifunctionality in 130 dryland sites in China, finding a shift towards greater importance of soil microbial diversity in arid conditions.

Weigang Hu
Jinzhi Ran
Jianming Deng
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-15
Association of triglycerides to high-density lipoprotein-cholesterol ratio with risk of incident hypertension

Dechen Liu
Li Guan
Jie Lu
Research24 Apr 2020
Hypertension Research

Volume: 43, P: 948-955
Association of pulse pressure with all-cause and cause-specific mortality

Dechen Liu
Pei Qin
Jie Lu
Research07 Apr 2020
Journal of Human Hypertension

Volume: 35, P: 274-279
RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation

Qingyang Wang
Silei Zhou
Jiyan Zhang
ResearchOpen Access18 Sept 2015
Scientific Reports

Volume: 5, P: 1-9
Neurons born in the adult dentate gyrus form functional synapses with target cells

Adult neurogenesis in hippocampus yields newly born granule cells that receive synaptic inputs from existing neurons. Characterizing morphological and functional features of newborn neurons in adult mice, Toni et al. demonstrate the functional maturation of their synaptic output onto the appropriate target cells in the hippocampus.

Nicolas Toni
Diego A Laplagne
Alejandro F Schinder
Research11 Jul 2008
Nature Neuroscience

Volume: 11, P: 901-907
Shotgun glycomics: a microarray strategy for functional glycomics

Derivatizing glycosphingolipids, extracted from bovine brain or human erythrocytes, with a fluorescent tag allows their immobilization on an array which can be probed with glycan binding proteins.

Xuezheng Song
Yi Lasanajak
David F Smith
Research05 Dec 2010
Nature Methods

Volume: 8, P: 85-90
Synapse formation on neurons born in the adult hippocampus

Nicolas Toni
E Matthew Teng
Fred H Gage
Research07 May 2007
Nature Neuroscience

Volume: 10, P: 727-734
Polymorphic regenerated silk fibers assembled through bioinspired spinning

Natural silk fibers are produced using a simple and green approach compared to alternative synthetic methods. Here, the authors show a bioinspired approach to spin regenerated silk fibers using anisotropic liquid crystals and dry spinning, resulting in remarkably robust fibers.

Shengjie Ling
Zhao Qin
Markus J. Buehler
ResearchOpen Access09 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Alcohol consumption and risks of more than 200 diseases in Chinese men

Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

Pek Kei Im
Neil Wright
Xiaoyi Zhang
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1476-1486
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

The Tet2 enzyme, which catalyses de novo hydroxymethylation of DNA, is shown here to act as a transcriptional repressor by recruiting the histone deacetylase Hdac2 to the Il6 promoter in the course of resolution of the LPS-induced inflammatory response.

Qian Zhang
Kai Zhao
Xuetao Cao
Research19 Aug 2015
Nature

Volume: 525, P: 389-393
DoGMP1 from Dendrobium officinale contributes to mannose content of water-soluble polysaccharides and plays a role in salt stress response

Chunmei He
Zhenming Yu
Jun Duan
ResearchOpen Access08 Feb 2017
Scientific Reports

Volume: 7, P: 1-13
Marine Autographiviridae phages exhibit high genetic diversity and global-scale biogeographic patterns

Metagenomic analyses of >1200 uncultivated marine Autographiviridae genomes reveal their diversity, host range, functional potential, and biogeography, providing key insights into their ecological roles.

Sen Du
Zuqing Wu
Yanlin Zhao
ResearchOpen Access18 Aug 2025
Communications Biology

Volume: 8, P: 1-13
Multilevel brain functional connectivity and task-based representations explaining heterogeneity in major depressive disorder

Qi Liu
Xinqi Zhou
Weihua Zhao
ResearchOpen Access13 Jun 2025
Translational Psychiatry

Volume: 15, P: 1-12
Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder

Qi Liu
Hua Lai
Weihua Zhao
ResearchOpen Access20 Jun 2025
Molecular Psychiatry

Volume: 30, P: 5034-5044
Notch keeps ependymal cells in line

The ependymal cells lining the lateral ventricles are not stem cells, but a study now shows that they can be activated to generate neuroblasts in a stroke model, and mature olfactory bulb neurons when Notch signaling is disrupted.

Chunmei Zhao
Hoonkyo Suh
Fred H Gage
News & Views01 Mar 2009
Nature Neuroscience

Volume: 12, P: 243-245
Author Correction: Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages

Wenhui Ren
Chunmei Wang
Nan Li
Amendments and CorrectionsOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1
Influence of rootstock on endogenous hormones and color change in Cabernet Sauvignon grapes

Zhiyu Liu
Chunmei Zhu
Baolong Zhao
ResearchOpen Access24 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
GmHs1-1, encoding a calcineurin-like protein, controls hard-seededness in soybean

Jianxin Ma and colleagues report the identification of a gene variant selected for during the domestication of soybean that causes permeable seed coats, in contrast to the hard seed coats of its wild ancestors. The identified gene, GmHs1-1, is predicted to encode a calcineurin-like metallophosphatase, although its cellular function remains unknown.

Lianjun Sun
Zhenyan Miao
Jianxin Ma
Research22 Jun 2015
Nature Genetics

Volume: 47, P: 939-943
Bacterial distributions and prognosis of bloodstream infections in patients with liver cirrhosis

Yangxin Xie
Bo Tu
Dongping Xu
ResearchOpen Access13 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
The Medicago genome provides insight into the evolution of rhizobial symbioses

Sequencing of Medicago truncatula, a model organism of legume biology, shows that genome duplications had a role in the evolution of endosymbiotic nitrogen fixation.

Nevin D. Young
Frédéric Debellé
Bruce A. Roe
ResearchOpen Access16 Nov 2011
Nature

Volume: 480, P: 520-524
Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo

Ayumu Tashiro
Chunmei Zhao
Fred H Gage
Protocols25 Jan 2007
Nature Protocols

Volume: 1, P: 3049-3055
Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages

Wenhui Ren
Chunmei Wang
Nan Li
ResearchOpen Access03 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Safety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma

Wen Lei
Ai Zhao
Wenbin Qian
ResearchOpen Access09 Jan 2024
Cell Discovery

Volume: 10, P: 1-14
Identification of an intraocular microbiota

Yuhua Deng
Xiaofei Ge
Lai Wei
ResearchOpen Access09 Mar 2021
Cell Discovery

Volume: 7, P: 1-12
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

Qicong Shen
Qian Zhang
Xuetao Cao
Research24 Jan 2018
Nature

Volume: 554, P: 123-127
The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts

Junjie Gu
Xuechun Li
Robert Chunhua Zhao
ResearchOpen Access17 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-13
A clustering approach identifies an Autism Spectrum Disorder subtype more responsive to chronic oxytocin treatment

Weihua Zhao
Jiao Le
Keith M. Kendrick
ResearchOpen Access29 Jul 2024
Translational Psychiatry

Volume: 14, P: 1-9
Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway

Pan Wu
Xiangchan Hou
Bo Xiang
Research12 May 2023
Cell Death & Differentiation

Volume: 30, P: 1679-1694
Proteomic profile of the Bradysia odoriphaga in response to the microbial secondary metabolite benzothiazole

Yunhe Zhao
Kaidi Cui
Wei Mu
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-15

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