Nature Search

Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation

Yunhan Zhang
Ying Zhang
Jianqiu Pei
ResearchOpen Access08 Jan 2026
Scientific Reports

P: 1-11
Design of highly efficient deep-blue organic afterglow through guest sensitization and matrices rigidification

Though realizing organic materials with deep blue emission is attractive for next-generation display technologies, achieving this emission in afterglow molecules remains a challenge. Here, the authors report blue organic afterglow via a strategy involving guest sensitization and matrix rigidification.

Shen Xu
Wu Wang
Wei Huang
ResearchOpen Access23 Sept 2020
Nature Communications

Volume: 11, P: 1-8
Viruses hijack FPN1 to disrupt iron withholding and suppress host defense

Here the authors show that viral infections facilitate accumulation of cellular iron by degradation of iron exporter ferroportin (FPN1), and that high intracellular iron suppresses type I IFN responses and autophagy by promoting TBK1 hydroxylation and STING carbonylation.

Li Tong
Jie Wang
Wei Zhao
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
A novel 3D indoor localization method integrating deep spatial feature augmentation and attention-based denoising

Chunyuan Liu
Xiaomin Yu
Haoyu Wang
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Convergence and divergence of diploid and tetraploid cotton genomes

High-quality assemblies of 15 diploid and 35 allotetraploid cotton accessions are analyzed in graph-based pan-genomes, providing insights into genome dynamics and regulatory control of fiber transcriptomes under varying ploidy and selection pressures.

Jianying Li
Zhenping Liu
Maojun Wang
Research29 Oct 2024
Nature Genetics

Volume: 56, P: 2562-2573
Glucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages

Glucocorticoids, potent anti-inflammatory drugs, can cause or exacerbate obesity, yet the underlying molecular mechanisms remain largely unknown. Here, the authors show KLF9 in macrophages integrates the beneficial anti-inflammatory and adverse metabolic effects of glucocorticoids.

Yinliang Zhang
Chunyuan Du
Yongsheng Chang
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-20
Correction: The harmful effects of acute PM2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

Lu Dong
Wenping Sun
Laiyu Song
Amendments and CorrectionsOpen Access16 Dec 2025
Scientific Reports

Volume: 15, P: 1-3
A clinically accessible small multimodal radiology model and evaluation metric for chest X-ray findings

Foundation models enable rapid adaptation to various downstream tasks and are hence about to become a new paradigm in biomedicine. Here, the authors develop LLaVA-Rad, a small AI that bests larger models in chest X-ray interpretation, and CheXprompt, a radiologist-aligned factuality metric, to enable scalable, privacy-preserving image analysis.

Juan Manuel Zambrano Chaves
Shih-Cheng Huang
Hoifung Poon
ResearchOpen Access01 Apr 2025
Nature Communications

Volume: 16, P: 1-15
UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

NLRP3 inflammasome activation is regulated by various signaling pathways to ensure inflammation does not go unchecked. Here the authors show how deubiquitination avoids this regulation to activate the NLRP3 inflammasome through the function of UAF1/USP deubiquitinase complexes.

Hui Song
Chunyuan Zhao
Wei Zhao
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Erratum: Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Xianqin Zhang
Dusan Bogunovic
Sandra Pellegrini
Amendments and Corrections11 Feb 2015
Nature

Volume: 519, P: 378
S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens

The generation of reactive oxygen and nitrogen species is an critical part of host defense against microbial infection. Here, Jia et al, characterize the mechanisms by which reactive nitrogen species can modulate innate immunity.

Mutian Jia
Li Chai
Wei Zhao
ResearchOpen Access26 Feb 2024
Nature Communications

Volume: 15, P: 1-12
A whole-slide foundation model for digital pathology from real-world data

Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.

Hanwen Xu
Naoto Usuyama
Hoifung Poon
ResearchOpen Access22 May 2024
Nature

Volume: 630, P: 181-188
The genomic basis of geographic differentiation and fiber improvement in cultivated cotton

Genomic variations in 3,248 tetraploid cotton germplasms and multi-environmental genome-wide association analyses provide insights into the basis of geographic differentiation and fiber improvement in cultivated cotton.

Shoupu He
Gaofei Sun
Xiongming Du
Research15 Apr 2021
Nature Genetics

Volume: 53, P: 916-924
Redox homeostasis maintained by GPX4 facilitates STING activation

Zhao and colleagues show that STING activation is sensitive to membrane lipid peroxidation that occurs upon reactive oxygen species (ROS) production. The lipid hydroperoxidase glutathione peroxidase 4 (GPX4) reduces such oxidized lipids. Lack of GPX4 leads to STING protein carbonylation, which impedes its trafficking from the ER to the Golgi.

Mutian Jia
Danhui Qin
Wei Zhao
Research15 Jun 2020
Nature Immunology

Volume: 21, P: 727-735
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

STING is an important component of the innate immune system involved in the direct response to the bacterial second messenger c-di-GMP. The structures of human STING in the presence and absence of c-di-GMP show how recognition of c-di-GMP is achieved by dimeric STING, providing a basis for future studies investigating signal transduction mechanisms.

Guijun Shang
Deyu Zhu
Lichuan Gu
Research24 Jun 2012
Nature Structural & Molecular Biology

Volume: 19, P: 725-727
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation

Stimulator of interferon gene (STING) plays critical roles in the host response to infection and in the production of interferon. Here the authors suggests myristic acid is involved in the homeostatic balancing of STING dependent autophagy and the interferon response.

Mutian Jia
Yuanyuan Wang
Wei Zhao
ResearchOpen Access07 Feb 2023
Nature Communications

Volume: 14, P: 1-12
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

Ying Qin
Qi Li
Wei Zhao
ResearchOpen Access09 Aug 2021
Nature Communications

Volume: 12, P: 1-9
An artificial intelligence model to predict mortality among hemodialysis patients: A retrospective validated cohort study

Zhong Peng
Shuzhu Zhong
Zhangxiu He
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Assessment of the embolization effect of temperature-sensitive p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels in the rabbit renal artery by CT perfusion and confirmed by macroscopic examination

Zhen Zhang
Chunyuan Cen
Ping Han
ResearchOpen Access01 Mar 2021
Scientific Reports

Volume: 11, P: 1-9
Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2

Chunyuan Jin
Kohsuke Kato
Kazunari K Yokoyama
Research05 Mar 2006
Nature Structural & Molecular Biology

Volume: 13, P: 331-338
Attribute reduction based on classes in incomplete ordered decision systems

Chunyuan Chen
Feng Yin
Jian Hu
ResearchOpen Access30 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Predicting the risk category of thymoma with machine learning-based computed tomography radiomics signatures and their between-imaging phase differences

Zhu Liang
Jiamin Li
Biao Deng
ResearchOpen Access19 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
GNG5 is a novel regulator of Aβ42 production in Alzheimer’s disease

Chunyuan Li
Yan Yang
Wei Ge
ResearchOpen Access11 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-21
Author Correction: Predicting the risk category of thymoma with machine learning-based computed tomography radiomics signatures and their between-imaging phase differences

Zhu Liang
Jiamin Li
Biao Deng
Amendments and CorrectionsOpen Access26 Mar 2025
Scientific Reports

Volume: 15, P: 1
Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization

Xiaofei Yue
Qiqi Jiang
Ping Han
ResearchOpen Access27 May 2021
Scientific Reports

Volume: 11, P: 1-10
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis

Chunyuan Yang
Nan Chen
Yuxin Yin
ResearchOpen Access02 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-15
TLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis

Jiajing Lu
Xiaoyuan Zhong
Yuling Shi
ResearchOpen Access09 May 2023
Cell Death & Disease

Volume: 14, P: 1-13
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.

Xianqin Zhang
Dusan Bogunovic
Sandra Pellegrini
Research12 Oct 2014
Nature

Volume: 517, P: 89-93
The harmful effects of acute PM_2.5 exposure to the heart and a novel preventive and therapeutic function of CEOs

Lu Dong
Wenping Sun
Laiyu Song
ResearchOpen Access05 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Pyrithione zinc alters mismatch repair to trigger tumor immunogenicity

Huanling Zhang
Jiaxin Wu
Zining Wang
Research15 Jan 2025
Oncogene

Volume: 44, P: 983-995
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis

Jianqiang Cai
Weilong Zhang
Hong Zhao
ResearchOpen Access23 Sept 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16
Prognostic values of left atrial strain analyzed by four-dimensional speckle tracking echocardiography in uremia with preserved ejection fraction

Lei Li
Chunyuan You
Pingyang Zhang
ResearchOpen Access16 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance

Polyploid giant cancer cells (PGCCs) have the properties of cancer stem cells, and cell-cycle-related proteins, including cyclin B1, CDC25B, and CDC25C play an important role in regulating the formation of PGCCs. This study shows that the phosphorylated proteins Chk2, and Aurora-A kinase regulate the expression and subcellular localization of cyclin B1, CDC25B, and CDC25C. The subcellular localization of these cell-cycle-related proteins is associated with pathologic grade and metastasis of tumors in cases of human breast cancer and ovarian cancer.

Fei Fei
Jie Qu
Shiwu Zhang
Research28 Nov 2018
Laboratory Investigation

Volume: 99, P: 483-498
Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits

Yuzhe Wang, Xuemin Cao et al. report the fine-mapping of a major growth trait QTL in chicken using genome-wide association and haplotype association analyses. They discover multiple mutations cumulatively contribute to the previously-reported QTL and identify one of a regulatory mutation that contributes to the variation in the measured traits.

Yuzhe Wang
Xuemin Cao
Ning Li
ResearchOpen Access28 Aug 2020
Communications Biology

Volume: 3, P: 1-13
Earliest giant panda false thumb suggests conflicting demands for locomotion and feeding

Xiaoming Wang
Denise F. Su
Tao Deng
ResearchOpen Access30 Jun 2022
Scientific Reports

Volume: 12, P: 1-13
Petrological evidence for deep subduction of organic carbon to subarc depths

Very light carbon isotopic signatures are observed in graphite trails within coesite-bearing garnet crystals in ultra-high pressure pelitic schists from the southwestern Tianshan, which suggests solid state transformation of subducted organic carbon.

Han Hu
Lifei Zhang
Zhicheng Liu
ResearchOpen Access16 Nov 2023
Communications Earth & Environment

Volume: 4, P: 1-9
TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression

TOB1 is identified as an interferon regulatory factor 3 (IRF3) binding partner that operates as a negative feedback inhibitor of IFNβ in toll-like receptor and cytosolic nucleic acid receptor sensing pathways.

Zhongxia Yu
Lijuan Wang
Mutian Jia
ResearchOpen Access09 Sept 2022
Communications Biology

Volume: 5, P: 1-8
Phenotypic and functional alterations of pDCs in lupus-prone mice

Zhenyuan Zhou
Jianyang Ma
Nan Shen
ResearchOpen Access16 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Unambiguous observation of shape effects on cellular fate of nanoparticles

Zhiqin Chu
Silu Zhang
Quan Li
ResearchOpen Access28 Mar 2014
Scientific Reports

Volume: 4, P: 1-9
A DNA-based method for studying root responses to drought in field-grown wheat genotypes

Chun Y. Huang
Haydn Kuchel
Alan C. McKay
ResearchOpen Access12 Nov 2013
Scientific Reports

Volume: 3, P: 1-7
Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Xue Zhou
Youdong Chen
Chunyuan Guo
ReviewsOpen Access24 Jan 2022
Cell Death & Disease

Volume: 13, P: 1-13

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