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Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry

Stopping chronic opioid use can lead to withdrawal. Here, authors show in mice that dampening activity of spinally projecting locus coeruleus neurons, targeting microglia, or blocking pannexin-1 channels alleviates opioid withdrawal.

Charlie H. T. Kwok
Erika K. Harding
Tuan Trang
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-17

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Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry

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