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Advanced filters: Author: Cian D’Arcy Clear advanced filters

  • Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy to target tumour metabolism indirectly.

    • Andrew Roe
    • Catríona M. Dowling
    • Tríona Ní Chonghaile
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17