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Showing 1–6 of 6 results
Advanced filters: Author: Ciaran Murphy-Royal Clear advanced filters

  • l-lactate is an important intercellular energy currency. Here the authors report a genetically encoded biosensor eLACCO1.1 to monitor extracellular l-lactate; they use eLACCO1.1 to image extracellular l-lactate in cultured mammalian cells and brain tissue.

    • Yusuke Nasu
    • Ciaran Murphy-Royal
    • Robert E. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Enduring changes in synaptic efficacy are highly sensitive to stress. Here, the authors show that astrocytic delivery of metabolites has an important role in the stress-mediated impairment of synaptic plasticity.

    • Ciaran Murphy-Royal
    • April D. Johnston
    • Grant R. Gordon
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • The authors find that glutamate release increases the diffusion of the astrocytic glutamate transporter GLT-1 in the plasma membrane. This activity-dependent increase in mobility facilitates glutamate clearance from the synaptic cleft, which influences the kinetics of excitatory post-synaptic events in rat hippocampal neurons.

    • Ciaran Murphy-Royal
    • Julien P Dupuis
    • Stéphane H R Oliet
    Research
    Nature Neuroscience
    Volume: 18, P: 219-226

  • Recent progress in astrocyte biology requires a more cohesive conceptual framework. This Perspective introduces a ‘contextual guidance’ paradigm in which astrocytes are key to adaptive modeling of neural circuits in response to state changes.

    • Ciaran Murphy-Royal
    • ShiNung Ching
    • Thomas Papouin
    Reviews
    Nature Neuroscience
    Volume: 26, P: 1848-1856