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Showing 1–2 of 2 results
Advanced filters: Author: Cindy Khuu Clear advanced filters

  • A combination of biochemical, single-molecule, and in vivo assays reveals that the UV-DDB complex that removes UV-induced DNA lesions via the nucleotide excision repair pathway also promotes removal of oxidative lesions via base excision repair.

    • Sunbok Jang
    • Namrata Kumar
    • Bennett Van Houten
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 695-703

  • Although circulating tumour DNA (ctDNA) can predict immune checkpoint blockade (ICB) responses, its association with tumour biomarkers remains unknown. Here, the authors use ctDNA to inform exome and transcriptome profiling of >100 patients with 30 cancer types on a single clinical ICB trial and identify tumour microenvironment features associated with response.

    • S. Y. Cindy Yang
    • Scott C. Lien
    • Trevor J. Pugh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15