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Showing 1–2 of 2 results
Advanced filters: Author: Clémence Mooser Clear advanced filters

  • DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.

    • Clémence Mooser
    • Ioanna-Eleni Symeonidou
    • Manuel Stucki
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.

    • Mara De Marco Zompit
    • Mònica Torres Esteban
    • Manuel Stucki
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16