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Showing 1–3 of 3 results
Advanced filters: Author: Claire Abeza Clear advanced filters

  • RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeostasis in mouse intestine, partly through destabilization of PI3K-like kinases, while elevated RPAP3 levels in colorectal tumors are associated with poor prognosis.

    • Chloé Maurizy
    • Claire Abeza
    • Bérengère Pradet-Balade
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone complex with PIH1D2 and RUVBL1/2 enriched in testis.

    • Chloé Maurizy
    • Marc Quinternet
    • Edouard Bertrand
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16