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Showing 1–19 of 19 results
Advanced filters: Author: Clara T. Bolton Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • New measurements of stable isotope vital effects in fossil coccoliths show a step increase in reliance of coccolithophore photosynthesis on active transport of dissolved bicarbonate in the late Miocene epoch, suggesting both a low threshold for adaptation of coccolithophores to carbon dioxide and a decrease in global carbon dioxide levels at that time.

    • Clara T. Bolton
    • Heather M. Stoll
    Research
    Nature
    Volume: 500, P: 558-562

  • The impact of future and past carbonate chemistry changes on calcifying plankton is poorly understood. Here, the authors show that coccolithophore degree of calcification decreased significantly between 6 and 4 million years ago, in line with declining aqueous CO2concentrations.

    • Clara T. Bolton
    • María T. Hernández-Sánchez
    • Heather M. Stoll
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511

  • The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.

    • Andrea Strakova
    • Thomas J. Nicholls
    • Elizabeth P. Murchison
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Rising global temperatures cause widespread bleaching of shallow coral reefs but mesophotic reefs at depths over 30 metres are thought to be sheltered by cooler waters. Here, at sites in the Chagos Archipelago, the authors show bleaching of corals at depths of 90 metres, which might be due to warm surface waters being pushed deeper by the ocean’s response to the Indian Ocean Dipole.

    • Clara Diaz
    • Nicola L. Foster
    • Phil Hosegood
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • .Morphometric analysis of coccolith assemblages spanning the last 2,800,000 years suggests that the evolution of coccolithophores is linked to seasonality changes, paced by Earth’s orbital eccentricity with implications for the carbon cycle.

    • Luc Beaufort
    • Clara T. Bolton
    • Martin Tetard
    Research
    Nature
    Volume: 601, P: 79-84

  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Machine learning methods in cheminformatics have made great progress in using chemical structures of molecules, but a large portion of textual information remains scarcely explored. Liu and colleagues trained MoleculeSTM, a foundation model that aligns the structure and text modalities through contrastive learning, and show its utility on the downstream tasks of structure–text retrieval, text-guided editing and molecular property prediction.

    • Shengchao Liu
    • Weili Nie
    • Animashree Anandkumar
    Research
    Nature Machine Intelligence
    Volume: 5, P: 1447-1457

  • A modern-like South Asian Monsoon only appeared when East African and Middle Eastern uplift led to the establishment of the Somali Jet around 13 million years ago, according to Earth system modelling using a range of regional palaeogeographies.

    • Anta-Clarisse Sarr
    • Yannick Donnadieu
    • Guillaume Dupont-Nivet
    Research
    Nature Geoscience
    Volume: 15, P: 314-319

  • One of the most remarkable global warming events in the history of the Earth was the Palaeocene–Eocene Thermal Maximum (PETM), 56 million years ago, which is thought to have been caused by the release of greenhouse gases from mineral weathering. Several other, less severe warming periods occurred around 6–8 million years after the PETM. This paper shows that these smaller events were brief and surprisingly frequent, to a tempo paced by the Earth's orbit. Their rapid onset and recovery indicates a mechanism primarily dependent on shuffling carbon between the atmosphere and a dissolved, organic form in the ocean, in sharp contrast to the PETM's more sluggish greenhouse gas release from buried carbon reservoirs.

    • Philip F. Sexton
    • Richard D. Norris
    • Samantha Gibbs
    Research
    Nature
    Volume: 471, P: 349-352

  • The autistic spectrum disorders (ASDs) are highly heritable, yet the underlying genetic determinants remain largely unknown. Here, a genome-wide analysis of rare copy number variants (CNVs) has been carried out, revealing that ASD sufferers carry a higher load of rare, genic CNVs than do controls. Many of these CNVs are de novo and inherited. The results implicate several novel genes in ASDs, and point to the importance of cellular proliferation, projection and motility, as well as specific signalling pathways, in these disorders.

    • Dalila Pinto
    • Alistair T. Pagnamenta
    • Catalina Betancur
    Research
    Nature
    Volume: 466, P: 368-372