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Showing 1–5 of 5 results
Advanced filters: Author: Clare Oliver-Williams Clear advanced filters

  • A meta-analysis of genome-wide association studies for 233 circulating metabolites from 33 cohorts reveals more than 400 loci and suggests probable causal genes, providing insights into metabolic pathways and disease aetiology.

    • Minna K. Karjalainen
    • Savita Karthikeyan
    • Johannes Kettunen
    ResearchOpen Access
    Nature
    Volume: 628, P: 130-138

  • A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.

    • Yu Xu
    • Scott C. Ritchie
    • Michael Inouye
    Research
    Nature
    Volume: 616, P: 123-131

  • A genetic atlas of the human plasma proteome, comprising 1,927 genetic associations with 1,478 proteins, identifies causes of disease and potential drug targets.

    • Benjamin B. Sun
    • Joseph C. Maranville
    • Adam S. Butterworth
    Research
    Nature
    Volume: 558, P: 73-79

  • Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using MR.

    • Laura B. L. Wittemans
    • Luca A. Lotta
    • Claudia Langenberg
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13