Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Clarissa Melo Czekster Clear advanced filters

  • Cyclodipeptide oxidases are filamentous enzymes. Here, the authors dissect the mechanism of a promiscuous flavoenzyme from the biosynthesis of cyclodipeptide natural products, unveiling fast catalysis for peptide oxidation in a distinct active site.

    • Emmajay Sutherland
    • Christopher J. Harding
    • Clarissa Melo Czekster
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The secreted aminopeptidase Pseudomonas aeruginosa aminopeptidase (PaAP) is required for nutrient recycling in biofilms. Using the information from protein structure and kinetics, a potent cyclic peptide inhibitor for PaAP was designed that killed cells in late-stage biofilms.

    • Christopher John Harding
    • Marcus Bischoff
    • Clarissa Melo Czekster
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1158-1166

  • Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates, however the substrate selection mechanism is not yet known. Here, the authors investigate the substrate promiscuity of two histidine-incorporating CDPSs to generate an extensive library of products which complement the chemical realm of histidine-containing cyclic dipeptides.

    • Emmajay Sutherland
    • Christopher John Harding
    • Clarissa Melo Czekster
    ResearchOpen Access
    Communications Chemistry
    Volume: 5, P: 1-10