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Showing 1–3 of 3 results
Advanced filters: Author: Claude Gazin Clear advanced filters

  • A genome-wide RNAi screen identifies several genes required for Ras-mediated epigenetic silencing that encode cell signalling molecules, chromatin modifiers, transcriptional activators and repressors, and the DNA methyltransferase DNMT1.

    • Claude Gazin
    • Narendra Wajapeyee
    • Michael R. Green
    Research
    Nature
    Volume: 449, P: 1073-1077

  • Cytidine deaminase (CDA) deficiency leads to genome instability. Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability.

    • Elias Bou Samra
    • Géraldine Buhagiar-Labarchède
    • Mounira Amor-Guéret
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The RING finger protein TRIM37 is encoded by a gene that is amplified in certain breast cancers, but its function is unknown; here, it is shown to mono-ubiquitinate histone H2A and repress gene expression, and to function as a breast cancer oncoprotein.

    • Sanchita Bhatnagar
    • Claude Gazin
    • Michael R. Green
    Research
    Nature
    Volume: 516, P: 116-120