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Showing 1–4 of 4 results
Advanced filters: Author: Claude Ostermann Clear advanced filters

  • Generating diverse structures with a minimum amount of synthetic effort is an important goal for drug discovery. Here, the authors report a two-phase synthesis for the generation of skeletally diverse small molecules—forming molecular scaffolds and subsequently diversifying each into multiple structures.

    • Miguel Garcia-Castro
    • Lea Kremer
    • Kamal Kumar
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • New natural-product-inspired molecules are often limited by their only partial coverage of biologically relevant chemical space. Combining fragments of natural products has now been shown to yield pseudo natural products, which — while still being inspired by natural products — populate previously unexplored areas of chemical space and have novel biological activities.

    • George Karageorgis
    • Elena S. Reckzeh
    • Herbert Waldmann
    Research
    Nature Chemistry
    Volume: 10, P: 1103-1111

  • The authors discuss the dysregulated host response in sepsis and the use of biomarkers to gauge the immunological status of patients and potentially guide precision medicine. They also highlight potential immunomodulatory therapies for sepsis and discuss the future of sepsis clinical trials.

    • Matthijs Kox
    • Michael Bauer
    • Peter Pickkers
    Reviews
    Nature Reviews Nephrology
    Volume: 22, P: 30-49