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Showing 1–3 of 3 results
Advanced filters: Author: Claudia Alleva Clear advanced filters

  • Sugar porters are textbook examples of how transport activity is described by Michaelis–Menten kinetics. Here, using saturation transfer difference nuclear magnetic resonance spectroscopy, Ahn et al. conclude that the fully occluded state of a sugar transporter is analogous to the transition state in soluble enzymes.

    • Do-Hwan Ahn
    • Claudia Alleva
    • David Drew
    ResearchOpen Access
    Nature Structural & Molecular Biology
    P: 1-12

  • Intracellular potassium (K+) homeostasis is achieved by activity of both ion channels and transporters. Here, the authors report structures of E. coli glutathione (GSH)-gated K+ efflux transporter KefC with bound K+ and conclude that the ion-binding site is adapted for binding a dehydrated ion.

    • Ashutosh Gulati
    • Surabhi Kokane
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • James Lupski and colleagues report a high-resolution analysis of 67 breakpoint junctions in 31 unrelated individuals with MECP2 duplication syndrome. They find that ~52% of genomic rearrangements in these individuals represent complex events in which the sequences flanking the breakpoints acquire additional changes, including small insertions, deletions and point mutations, likely resulting from error-prone DNA polymerase activity.

    • Claudia M B Carvalho
    • Davut Pehlivan
    • James R Lupski
    Research
    Nature Genetics
    Volume: 45, P: 1319-1326