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Showing 1–6 of 6 results
Advanced filters: Author: Claudia Bonfio Clear advanced filters

  • Current mineral-based theories do not fully address how enzymes emerged from prebiotic catalysts. Now, iron–sulfur clusters can be synthesized by UV-light-mediated photolysis of organic thiols and photooxidation of ferrous ions. Iron–sulfur peptides may have formed easily on early Earth, facilitating the emergence of iron–sulfur-cluster-dependent metabolism.

    • Claudia Bonfio
    • Luca Valer
    • Sheref S. Mansy
    Research
    Nature Chemistry
    Volume: 9, P: 1229-1234

  • How did the biological machinery for protein synthesis evolve from simple chemicals on ancient Earth? Experiments suggest an intriguing role for modified RNA nucleotides in directing stepwise peptide synthesis.

    • Claudia Bonfio
    News & Views
    Nature
    Volume: 605, P: 231-232

  • Mixtures of peptides and nucleic acids tend to demix and form coacervate droplets. Here, the authors show that even short peptides and oligonucleotides form droplets. DNA and RNA impart different properties to these protocells – stability, fluidity and the potential to host RNA chemistry.

    • Karina K. Nakashima
    • Fatma Zohra Mihoubi
    • Claudia Bonfio
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The bioenergetic metabolism of all life today depends on proton gradients; however, it remains unclear how such gradients developed in early life. Here, Mansy and co-workers establish a possible prebiotic mechanism in which iron–sulfur peptide redox networks generate a trans-membrane pH gradient.

    • Claudia Bonfio
    • Elisa Godino
    • Sheref S. Mansy
    Research
    Nature Catalysis
    Volume: 1, P: 616-623

  • Life requires a constant supply of energy, but the energy sources that drove the transition from prebiotic chemistry to biochemistry on the early Earth are unknown. Now, a potentially prebiotic chemical activating reagent has been shown to enable the synthesis, in aqueous conditions and catalysed by small molecules, of peptides, peptidyl–RNAs, RNA oligomers and primordial phospholipids.

    • Ziwei Liu
    • Long-Fei Wu
    • John D. Sutherland
    Research
    Nature Chemistry
    Volume: 12, P: 1023-1028