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Showing 1–2 of 2 results
Advanced filters: Author: Claudia Fogl Clear advanced filters

  • Plakin proteins link cell junctions to cytoskeletal frameworks, and their disruption within epithelial and cardiac muscle cells cause skin blistering diseases and cardiomyopathies. Here the authors use structural biology approaches to reveal the mechanism that allows plakins to recognize intermediate filaments within the cytoskeleton.

    • Claudia Fogl
    • Fiyaz Mohammed
    • Martyn Chidgey
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Odinstova, Mohammed, Trieber et al. use structure-based mutagenesis to identify key residues in human periplakin and desmoplakin linker modules required for co-localization with vimentin intermediate filaments. They show that vimentin D176 and E187 are required for direct binding with the periplakin linker.

    • Elena Odintsova
    • Fiyaz Mohammed
    • Michael Overduin
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13