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Showing 1–7 of 7 results
Advanced filters: Author: Claudia Gerri Clear advanced filters

  • The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vessel repair.

    • Claudia Gerri
    • Rubén Marín-Juez
    • Didier Y R. Stainier
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • DNA nanotechnology is used to develop fully synthetic, programmable and printable 3D cell-culture matrices with stress-relaxation crosslinkers that encode (nano)mechanical stability. The hydrogel performs on par with solubilized animal-basement-membrane-derived cell-culture matrices.

    • Yu-Hsuan Peng
    • Syuan-Ku Hsiao
    • Elisha Krieg
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 18, P: 1463-1473

  • The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sustain hESCs in the absence of FGF.

    • Sissy E. Wamaitha
    • Katarzyna J. Grybel
    • Kathy K. Niakan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Transcriptional adaptation, a genetic compensation process by which organisms respond to mutations by upregulating related genes, is triggered by mRNA decay and involves a sequence-dependent mechanism.

    • Mohamed A. El-Brolosy
    • Zacharias Kontarakis
    • Didier Y. R. Stainier
    Research
    Nature
    Volume: 568, P: 193-197

  • Zebrafish embryos injected with egfl7 morpholino exhibit severe vascular defects but egfl7 mutants do not show any obvious phenotypes, illustrating the power of comparing mutants and morphants to identify modifier genes.

    • Andrea Rossi
    • Zacharias Kontarakis
    • Didier Y. R. Stainier
    Research
    Nature
    Volume: 524, P: 230-233