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Showing 1–3 of 3 results
Advanced filters: Author: Claudia Trappetti Clear advanced filters

  • Pneumococci can alternate between harmless and highly virulent forms. Here the authors show that such variation may be due to random rearrangements in a genetic locus encoding a restriction-modification system, resulting in epigenetic changes that affect expression of many genes.

    • Ana Sousa Manso
    • Melissa H. Chai
    • Marco R. Oggioni
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-9

  • Streptococcus pneumoniae strains colonizing the nasopharynx use quorum sensing and fratricide to outcompete incoming strains, thereby retaining ownership of the host. This occurs via activation of the competence regulon, induction of lytic proteins, and turning the invader into a source of DNA for genetic exchange.

    • James C. Paton
    • Claudia Trappetti
    News & Views
    Nature Microbiology
    Volume: 4, P: 8-9

  • Minhas, Aprianto et al. apply dual RNA seq to a set of related Streptococcus pneumoniae strains to find that differential neutrophil recruitment explains different tissue tropism of these strains. This study highlights the power of dual RNA-seq in investigating how a single bacterial SNP determines the host’s disease outcomes.

    • Vikrant Minhas
    • Rieza Aprianto
    • Claudia Trappetti
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12