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Showing 1–3 of 3 results
Advanced filters: Author: Claudio L. Morales-Perez Clear advanced filters

  • Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired properties and functions.

    • John B. Ingraham
    • Max Baranov
    • Gevorg Grigoryan
    ResearchOpen Access
    Nature
    Volume: 623, P: 1070-1078

  • Cryo-electron microscopy structures of two stoichiometries of heteromeric acetylcholine receptors in complex with nicotine reveal principles of subunit assembly and the structural basis of the distinctive biophysical and pharmacological properties of the different stoichiometries.

    • Richard M. Walsh Jr
    • Soung-Hun Roh
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 557, P: 261-265

  • Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a nicotinic receptor is reported, revealing how nicotine stabilizes the receptor in a non-conducting, desensitized conformation.

    • Claudio L. Morales-Perez
    • Colleen M. Noviello
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 538, P: 411-415