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Showing 1–3 of 3 results

Advanced filters: Author: Clea Bárcena Clear advanced filters

A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.

Clea Bárcena
Carlos López-Otín
News & Views31 Aug 2017
Nature Cell Biology

Volume: 19, P: 1012-1013
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

Fecal microbiome transplantation or probiotic therapy with Akkermansia muciniphila extends the lifespan and improves the health status of progeroid mice, pointing to the importance of the gut microbiome in regulating lifespan and healthspan.

Clea Bárcena
Rafael Valdés-Mas
Carlos López-Otín
Research22 Jul 2019
Nature Medicine

Volume: 25, P: 1234-1242
Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

Álvaro F Fernández
Clea Bárcena
Guillermo Mariño
ResearchOpen Access03 Aug 2017
Cell Death & Disease

Volume: 8, P: e2970