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Showing 1–2 of 2 results
Advanced filters: Author: Clemence Blouet Clear advanced filters

  • The dorsal raphe nucleus (DRN) is emerging as a key regulator of food intake and energy expenditure but the molecular and functional heterogeneity of DRN neurons is largely unknown. A new study characterizes the role of glutamatergic DRN neurons in the control of food intake and identifies a pharmacological approach to target these neurons in obesity.

    • Anthony Tsang
    • Clemence Blouet
    News & Views
    Nature Reviews Endocrinology
    Volume: 19, P: 190-191

  • Folgueira et al. show that dopamine signalling in the lateral hypothalamic area and the zona incerta reduces body weight and increases energy expenditure by increasing brown adipose tissue thermogenesis in rodents. Weight loss and increased energy expenditure were also observed in patients treated with a dopamine receptor 2 agonist.

    • Cintia Folgueira
    • Daniel Beiroa
    • Ruben Nogueiras
    Research
    Nature Metabolism
    Volume: 1, P: 811-829