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Showing 1–10 of 10 results
Advanced filters: Author: Clemens Glaubitz Clear advanced filters

  • As protein synthesis takes place, newly synthesized polypeptide chain passes through the ribosomal exit tunnel, which can accommodate up to 70 residues in the case of a helical peptide. Here the authors show that oxidation of cysteine residues in the nascent chain can occur within the ribosome exit tunnel, where sufficient space exists for the formation of disulfide bonds.

    • Linda Schulte
    • Jiafei Mao
    • Harald Schwalbe
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Magic-angle spinning ssNMR used to monitor the E. coli integral membrane protein DGK reconstituted into lipid bilayers reveals the kinetics and mechanisms of this enzyme in both the membrane phase where diacylglycerol is converted to PA and in the aqueous phase where ATP is converted to ADP.

    • Sandra J Ullrich
    • Ute A Hellmich
    • Clemens Glaubitz
    Research
    Nature Chemical Biology
    Volume: 7, P: 263-270

  • ATP-binding cassette (ABC) transporters hydrolyse ATP to transport molecules across the cell membrane. Here Vogelet al. show that the ABC exporter MsBA can couple ATP hydrolyse to an adenylate kinase activity that seems to be predominant at low ATP levels and a general feature of ABC exporters.

    • Hundeep Kaur
    • Andrea Lakatos-Karoly
    • Clemens Glaubitz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • NMR to resolve the subtype specificity of two peptide ligands for human bradykinin receptors B1R and B2R shows different presentations of the peptide termini toward the receptor and interactions with nonconserved receptor binding-pocket residues.

    • Lisa Joedicke
    • Jiafei Mao
    • Clemens Glaubitz
    Research
    Nature Chemical Biology
    Volume: 14, P: 284-290

  • Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy. They compare the structure with structures solved by solution NMR and X-ray crystallography and provide insights into the influence of membrane mimetic environments on membrane proteins.

    • Jianping Li
    • Yang Shen
    • Jun Yang
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13

  • Dynamic nuclear polarization (DNP) greatly improves the NMR sensitivity, but its implementation in aqueous solutions is challenging. Here the authors demonstrate carbon polarization enhancement via in situ Overhauser DNP in small biomolecules in water at room temperature and high magnetic field.

    • Danhua Dai
    • Xianwei Wang
    • Jiafei Mao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition of its production can rescue vascular abnormalities in a mouse model of the disease.

    • Jiong Hu
    • Sarah Dziumbla
    • Ingrid Fleming
    Research
    Nature
    Volume: 552, P: 248-252