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Showing 1–12 of 12 results
Advanced filters: Author: Colby Lewis V Clear advanced filters

  • Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.

    • Sebastian Scheer
    • Suzanne Ackloo
    • Cheryl H. Arrowsmith
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

    • Xin Li
    • Yungil Kim
    • Stephen B. Montgomery
    ResearchOpen Access
    Nature
    Volume: 550, P: 239-243

  • The GREGoR consortium provides foundational resources and substrates for the future of rare disease genomics.

    • Moez Dawood
    • Ben Heavner
    • Gabrielle C. Villard
    Reviews
    Nature
    Volume: 647, P: 331-342

  • Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

    • François Aguet
    • Andrew A. Brown
    • Jingchun Zhu
    ResearchOpen Access
    Nature
    Volume: 550, P: 204-213

  • Neotropical tree community composition shows opposing successional pathways for wet and dry forests, but as vegetation cover increases over time, trends converge. Selecting species that have similar wood density to early successional communities could improve reforestation prospects.

    • Lourens Poorter
    • Danaë M. A. Rozendaal
    • Mark Westoby
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 928-934

  • Multiple transcriptome approaches, including single-cell sequencing, demonstrate that escape from X chromosome inactivation is widespread and occasionally variable between cells, chromosomes, and tissues, resulting in sex-biased expression of at least 60 genes and potentially contributing to sex-specific differences in health and disease.

    • Taru Tukiainen
    • Alexandra-Chloé Villani
    • Daniel G. MacArthur
    ResearchOpen Access
    Nature
    Volume: 550, P: 244-248

  • Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.

    • Alvaro N. Barbeira
    • Scott P. Dickinson
    • Hae Kyung Im
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-20

  • Comparison of representation of blind and deaf participants in the All of Us Research Program (AoURP) with CDC national estimates demonstrates that these populations are underrepresented in the AoURP cohort, raising concerns about the generalizability of findings generated using this dataset.

    • Colby Lewis V
    • Jack Huebner
    • Maya Sabatello
    Research
    Nature Medicine
    Volume: 29, P: 2742-2747

  • Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • Qin Li
    • Jin Billy Li
    Research
    Nature
    Volume: 550, P: 249-254

  • Stephen Wright, Detlef Weigel and colleagues report the whole-genome sequence of Capsella rubella, a highly selfing crucifer found throughout much of southern and western Europe. They compare mixed-stage flower bud transcriptomes from C. rubella and C. grandiflora, finding a shift in expression of genes associated with flowering phenotypes and providing insights into the transition to selfing.

    • Tanja Slotte
    • Khaled M Hazzouri
    • Stephen I Wright
    ResearchOpen Access
    Nature Genetics
    Volume: 45, P: 831-835