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Showing 1–5 of 5 results
Advanced filters: Author: Colette Reilly Clear advanced filters

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Evidence from trials suggests SARS-CoV-2 binding antibody thresholds could serve as surrogate markers of neutralising capacity, but whether this is accurate in the context of variants of concerns, or in the event of prior infection or vaccination remains unclear. Authors explore the performance of receptor binding domain IgG thresholds in predicting a level of neutralising capacity that has demonstrated protection against infection in vaccine trials

    • Grace Kenny
    • Sophie O’Reilly
    • Patrick Mallon
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Dowling-Cullen, Fahey et al., describe the clinical, laboratory, and epidemiologic features of a case of monkeypox virus clade Ia infection detected in Dublin, Ireland. Phylogenetic analysis and APOBEC3-associated mutation profiling place the viral genome obtained from this case in an evolving cluster of infections in the Democratic Republic of the Congo, drawing attention to recent changes in the epidemiology of this virus with evidence supporting sustained human-to-human transmission.

    • Cian Dowling-Cullen
    • Laura Fahey
    • Derval Igoe
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-8