Nature Search

Screening, large-scale production and structure-based classification of cystine-dense peptides

A platform for high-throughput expression screening and large-scale production of cystine-dense peptides, alongside a global structure-based classification, is presented.

Colin E. Correnti
Mesfin M. Gewe
Roland K. Strong
Research26 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 270-278
Proof of principle for epitope-focused vaccine design

Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine; artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques.

Bruno E. Correia
John T. Bates
William R. Schief
Research05 Feb 2014
Nature

Volume: 507, P: 201-206
Accurate de novo design of hyperstable constrained peptides

Computational methods for the de novo design of conformationally restricted peptides produce exceptionally stable short peptides stabilized by backbone cyclization and/or internal disulfide bonds that are promising starting points for a new generation of peptide-based drugs.

Gaurav Bhardwaj
Vikram Khipple Mulligan
David Baker
Research14 Sept 2016
Nature

Volume: 538, P: 329-335
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model

Andrew T. McGuire
Matthew D. Gray
Leonidas Stamatatos
ResearchOpen Access24 Feb 2016
Nature Communications

Volume: 7, P: 1-10
TNIK signaling imprints CD8⁺ T cell memory formation early after priming

Coordinate expression of multiple factors play critical roles in the regulation between effector and memory CD8⁺ T cell differentiation. Here the authors show upon acute viral infection TNIK is critically required as a regulator of effector and memory T cell differentiation.

Carla A. Jaeger-Ruckstuhl
Magdalena Hinterbrandner
Adrian F. Ochsenbein
ResearchOpen Access02 Apr 2020
Nature Communications

Volume: 11, P: 1-16
Engineering and functionalization of large circular tandem repeat protein nanoparticles

Circular nanoparticles self-assembled from designed tandem repeat proteins are functionalized by fusing different protein domains at defined positions and copy numbers. These constructs can activate T cells via high-avidity interactions on the cell surface.

Colin E. Correnti
Jazmine P. Hallinan
Philip Bradley
Research23 Mar 2020
Nature Structural & Molecular Biology

Volume: 27, P: 342-350
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications. Here, the authors perform whole gene and transcript-level analyses and report the TrkB.T1 splice variant enhances PDGF-driven gliomas in vivo and augments PI3K signaling cascades in vitro.

Siobhan S. Pattwell
Sonali Arora
Eric C. Holland
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation

Colin E. Correnti
George S. Laszlo
Roland B. Walter
Research31 Jan 2018
Leukemia

Volume: 32, P: 1239-1243
The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

Colin D. Godwin
George S. Laszlo
Roland B. Walter
Research18 Feb 2020
Leukemia

Volume: 34, P: 2479-2483
Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy

Colin D. Godwin
George S. Laszlo
Roland B. Walter
Research15 Feb 2021
Leukemia

Volume: 35, P: 2496-2507

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Screening, large-scale production and structure-based classification of cystine-dense peptides

Proof of principle for epitope-focused vaccine design

Accurate de novo design of hyperstable constrained peptides

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

TNIK signaling imprints CD8⁺ T cell memory formation early after priming

Engineering and functionalization of large circular tandem repeat protein nanoparticles

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation

The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia

Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy

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