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Showing 1–4 of 4 results

Advanced filters: Author: Colin Hemez Clear advanced filters

Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

Mary S. Morrison
Tina Wang
David R. Liu
Amendments and CorrectionsOpen Access17 Nov 2021
Nature Communications

Volume: 12, P: 1
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

A systematic implementation of six efficiency optimizations for prime editing led to high levels of functional correction, in airway epithelial cells, of the predominant mutation that causes cystic fibrosis.

Alexander A. Sousa
Colin Hemez
David R. Liu
ResearchOpen Access10 Jul 2024
Nature Biomedical Engineering

Volume: 9, P: 7-21
Engineering a genomically recoded organism with one stop codon

Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into proteins.

Michael W. Grome
Michael T. A. Nguyen
Farren J. Isaacs
ResearchOpen Access05 Feb 2025
Nature

Volume: 639, P: 512-521
Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

The directed evolution of antibodies yields important tools for research and therapy. Here the authors develop a periplasmic phage-assisted continuous evolution platform for improvement of protein-protein interactions in the disulfidecompatible E. coli periplasm.

Mary S. Morrison
Tina Wang
David R. Liu
ResearchOpen Access13 Oct 2021
Nature Communications

Volume: 12, P: 1-14