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Showing 1–13 of 13 results
Advanced filters: Author: Colin J. Akerman Clear advanced filters

  • Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in utero progenitor labeling techniques with targeted Patch-Seq methods and high resolution synaptic circuit mapping in the mature mouse cortex to show that intermediate progenitors can generate restricted sets of transcriptomically-defined glutamatergic neurons that have distinct patterns of local and long-range synaptic connections.

    • Tommas J. Ellender
    • Sophie V. Avery
    • Colin J. Akerman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Alfonsa et al. show that wakefulness causes shifts in cortical EGABAA, weakening synaptic inhibition and resulting in markers of local sleep pressure, and identify Cl− regulation as a link between sleep–wake history, cortical activity and behavior.

    • Hannah Alfonsa
    • Richard J. Burman
    • Colin J. Akerman
    Research
    Nature Neuroscience
    Volume: 26, P: 64-78

  • Multi-layered neural architectures that implement learning require elaborate mechanisms for symmetric backpropagation of errors that are biologically implausible. Here the authors propose a simple resolution to this problem of blame assignment that works even with feedback using random synaptic weights.

    • Timothy P. Lillicrap
    • Daniel Cownden
    • Colin J. Akerman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • In this study, the authors show that optogenetic silencing of neurons with a commonly used light-driven chloride pump can result in alterations in GABAergic synaptic transmission that persist after the stimulation period and that may result in changes to neuronal excitability.

    • Joseph V Raimondo
    • Louise Kay
    • Colin J Akerman
    Research
    Nature Neuroscience
    Volume: 15, P: 1102-1104

  • Single-cell intracellular recordings have been used as the primary tool for estimating driving forces across inhibitory receptors within the nervous system. Here, the authors present ORCHID as an all-optical method to measure inhibitory receptor driving forces in targeted brain cell types.

    • Joshua S. Selfe
    • Teresa J. S. Steyn
    • Joseph V. Raimondo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Receptive fields in the developing frog optic tectum are refined under the influence of visual inputs. Richards and colleagues find that these changes require intra-tectal GABAergic transmission. Blockade of GABA signaling increased correlated activity in the tectum. The authors argue that GABA signaling acts to set a low 'background noise' of correlated activity that allows relevant spike timing–dependent plasticity to reshape intra-tectal synapses and thereby reshape receptive fields.

    • Blake A Richards
    • Oliver P Voss
    • Colin J Akerman
    Research
    Nature Neuroscience
    Volume: 13, P: 1098-1106

  • The conventional view is that the cortex generates brain oscillations, while subcortical structures control global sleep–wake switching. This study shows that the cortex plays an important role in both global state control and sleep homeostasis.

    • Lukas B. Krone
    • Tomoko Yamagata
    • Vladyslav V. Vyazovskiy
    Research
    Nature Neuroscience
    Volume: 24, P: 1210-1215

  • The backpropagation of error (backprop) algorithm is frequently used to train deep neural networks in machine learning, but it has not been viewed as being implemented by the brain. In this Perspective, however, Lillicrap and colleagues argue that the key principles underlying backprop may indeed have a role in brain function.

    • Timothy P. Lillicrap
    • Adam Santoro
    • Geoffrey Hinton
    Reviews
    Nature Reviews Neuroscience
    Volume: 21, P: 335-346

  • Many episodes of status epilepticus do not respond to first-line treatment with benzodiazepines. In this Perspective, Richard Burman and colleagues discuss seizure-induced alterations to the sensitivity of the GABA receptor to benzodiazepines, presenting these changes as a possible mechanism of treatment resistance.

    • Richard J. Burman
    • Richard E. Rosch
    • Joseph V. Raimondo
    Reviews
    Nature Reviews Neurology
    Volume: 18, P: 428-441