Nature Search

Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics

Anna L. Koessinger
Catherine Cloix
Stephen W. G. Tait
ResearchOpen Access26 Apr 2022
Cell Death & Differentiation

Volume: 29, P: 2089-2104
Author Correction: Global status and conservation potential of reef sharks

M. Aaron MacNeil
Demian D. Chapman
Joshua E. Cinner
Amendments and Corrections27 Aug 2020
Nature

Volume: 585, P: E11
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England

Genetic and testing data from England show that the SARS-CoV-2 variant of concern B.1.1.7 has a transmission advantage over other lineages.

Erik Volz
Swapnil Mishra
Neil M. Ferguson
Research25 Mar 2021
Nature

Volume: 593, P: 266-269
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi

Allan D. C. Chilimba
Scott D. Young
Martin R. Broadley
ResearchOpen Access23 Aug 2011
Scientific Reports

Volume: 1, P: 1-9
Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Multi-nucleotide variants (MNV) are genetic variants in close proximity of each other on the same haplotype whose functional impact is difficult to predict if they reside in the same codon. Here, Wang et al. use the gnomAD dataset to assemble a catalogue of MNVs and estimate their global mutation rate.

Qingbo Wang
Emma Pierce-Hoffman
Daniel G. MacArthur
ResearchOpen Access27 May 2020
Nature Communications

Volume: 11, P: 1-13
Rainfall as a trigger of ecological cascade effects in an Australian groundwater ecosystem

Mattia Saccò
Alison J. Blyth
Kliti Grice
ResearchOpen Access12 Feb 2021
Scientific Reports

Volume: 11, P: 1-15
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Upstream open reading frames (uORFs), located in 5’ untranslated regions, are regulators of downstream protein translation. Here, Whiffin et al. use the genomes of 15,708 individuals in the Genome Aggregation Database (gnomAD) to systematically assess the deleteriousness of variants creating or disrupting uORFs.

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
ResearchOpen Access27 May 2020
Nature Communications

Volume: 11, P: 1-12
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Amino acid PET for brain tumours — ready for the clinic?

The Response Assessment in Neuro-Oncology Working Group has analysed the role of clinically established PET methods in the diagnostic assessment of brain tumours. The group emphasizes the clinical value of PET imaging, particularly amino acid PET imaging, over conventional MRI, and recommends its use at every stage of management.

Karl-Josef Langen
Colin Watts
News & Views10 Jun 2016
Nature Reviews Neurology

Volume: 12, P: 375-376
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Dendritic cells spill the beans

Colin Watts
News & Views01 Oct 1999
Nature Cell Biology

Volume: 1, P: E152-E154
Correcting the drug development paradigm for glioblastoma requires serial tissue sampling

A breakthrough in drug discovery for glioblastoma requires serial collection of tissue from the central nervous system via window of opportunity trials

Kirit Singh
Kelly M. Hotchkiss
Mustafa Khasraw
Comments & Opinion24 Jul 2023
Nature Medicine

Volume: 29, P: 2402-2405
Immunology Inside the gearbox of the dendritic cell

Colin Watts
News & Views21 Aug 1997
Nature

Volume: 388, P: 724
Averting biodiversity collapse in tropical forest protected areas

Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.

William F. Laurance
D. Carolina Useche
Franky Zamzani
Research25 Jul 2012
Nature

Volume: 489, P: 290-294
Author Correction: Transcript expression-aware annotation improves rare variant interpretation

Beryl B. Cummings
Konrad J. Karczewski
Daniel G. MacArthur
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E54
Evaluating drug targets through human loss-of-function genetic variation

Analysis of predicted loss-of-function variants from 125,748 human exomes and 15,708 whole genomes in the Genome Aggregation Database (gnomAD) provides a roadmap for human ‘knockout’ studies and a guide for future research into disease biology and drug-target selection.

Eric Vallabh Minikel
Konrad J. Karczewski
Daniel G. MacArthur
ResearchOpen Access27 May 2020
Nature

Volume: 581, P: 459-464
The molecular landscape of glioma in patients with Neurofibromatosis 1

An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.

Fulvio D’Angelo
Michele Ceccarelli
Antonio Iavarone
Research10 Dec 2018
Nature Medicine

Volume: 25, P: 176-187
Redefine statistical significance

We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.

Daniel J. Benjamin
James O. Berger
Valen E. Johnson
Comments & Opinion01 Sept 2017
Nature Human Behaviour

Volume: 2, P: 6-10
Author Correction: A structural variation reference for medical and population genetics

Ryan L. Collins
Harrison Brand
Michael E. Talkowski
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E55
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski
Laurent C. Francioli
Daniel G. MacArthur
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E53
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen
Laurent C. Francioli
Konrad J. Karczewski
Amendments and Corrections15 Jan 2024
Nature

Volume: 626, P: E1
Combining conventional QTL analysis and whole-exome capture-based bulk-segregant analysis provides new genetic insights into tuber sprout elongation and dormancy release in a diploid potato population

Sanjeev Kumar Sharma
Karen McLean
Glenn J. Bryan
ResearchOpen Access30 Jul 2021
Heredity

Volume: 127, P: 253-265
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

Colin Watts
Reviews28 Jun 2004
Nature Immunology

Volume: 5, P: 685-692
The effect of LRRK2 loss-of-function variants in humans

Analysis of large genomic datasets, including gnomAD, reveals that partial LRRK2 loss of function is not strongly associated with diseases, serving as an example of how human genetics can be leveraged for target validation in drug discovery.

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
ResearchOpen Access27 May 2020
Nature Medicine

Volume: 26, P: 869-877
Vascular endothelial growth factor signaling requires glycine to promote angiogenesis

Dongqing Guo
Colin E. Murdoch
Yuchun Gu
ResearchOpen Access07 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Exploring genetic influences underlying acute aerobic exercise effects on motor learning

Cameron S. Mang
Lisa M. McEwen
Lara A. Boyd
ResearchOpen Access21 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma

Irwin McLean and colleagues report that heterozygous loss-of-function mutations in AAGAB, which encodes a cytosolic protein implicated in vesicular trafficking, cause punctate palmoplantar keratoderma. They further show that knockdown of AAGAB in keratinocytes leads to increased cell proliferation accompanied by highly elevated levels of epidermal growth factor receptor.

Elizabeth Pohler
Ons Mamai
W H Irwin McLean
Research14 Oct 2012
Nature Genetics

Volume: 44, P: 1272-1276
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals

Nicola Whiffin
Konrad J. Karczewski
James S. Ware
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
Author Correction: Evaluating drug targets through human loss-of-function genetic variation

Eric Vallabh Minikel
Konrad J. Karczewski
Daniel G. MacArthur
Amendments and CorrectionsOpen Access03 Feb 2021
Nature

Volume: 590, P: E56
Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma

Eun-Ang Raiber
Dario Beraldi
Shankar Balasubramanian
ResearchOpen Access13 Mar 2017
npj Genomic Medicine

Volume: 2, P: 1-7
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Sanna Gudmundsson
Konrad J. Karczewski
Daniel G. MacArthur
Amendments and CorrectionsOpen Access09 Aug 2021
Nature

Volume: 597, P: E3-E4
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
Author Correction: The effect of LRRK2 loss-of-function variants in humans

Nicola Whiffin
Irina M. Armean
Daniel G. MacArthur
Amendments and Corrections22 Jan 2021
Nature Medicine

Volume: 27, P: 355
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes

Qingbo Wang
Emma Pierce-Hoffman
Daniel G. MacArthur
Amendments and CorrectionsOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Grace Collord
Patrick Tarpey
Ultan McDermott
ResearchOpen Access10 Sept 2018
Scientific Reports

Volume: 8, P: 1-13
An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder

Sarah M. Williams
Joon Yong An
Charles Claudianos
ResearchOpen Access27 Apr 2018
Molecular Psychiatry

Volume: 24, P: 1707-1719
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Soil-type influences human selenium status and underlies widespread selenium deficiency risks in Malawi

Rachel Hurst
Edwin W. P. Siyame
Martin R. Broadley
ResearchOpen Access12 Mar 2013
Scientific Reports

Volume: 3, P: 1-6
Host genetic background influences diverse neurological responses to viral infection in mice

Candice L. Brinkmeyer-Langford
Raquel Rech
David W. Threadgill
ResearchOpen Access22 Sept 2017
Scientific Reports

Volume: 7, P: 1-17
Methanethiol-dependent dimethylsulfide production in soil environments

Ornella Carrión
Jennifer Pratscher
Jonathan D Todd
ResearchOpen Access01 Aug 2017
The ISME Journal

Volume: 11, P: 2379-2390
EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer

Jennifer L Clancy
Michelle J Henderson
Colin KW Watts
Research06 Aug 2003
Oncogene

Volume: 22, P: 5070-5081
Wearable sensors for monitoring the internal and external workload of the athlete

Dhruv R. Seshadri
Ryan T. Li
Colin K. Drummond
ReviewsOpen Access29 Jul 2019
npj Digital Medicine

Volume: 2, P: 1-18

Search

Filter By:

Search

Quick links