Nature Search

A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Tegavivint triggers TECR-dependent nonapoptotic cancer cell death

In chemical-genetic and lipidomics analyses, the clinical candidate oncology drug tegavivint induced an unconventional form of nonapoptotic cell death that required the lipid metabolic enzyme trans-2,3-enoyl-CoA reductase.

Logan Leak
Ziwei Wang
Scott J. Dixon
Research26 May 2025
Nature Chemical Biology

Volume: 21, P: 1873-1884
Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Mark P. Purdue
Diptavo Dutta
Stephen J. Chanock
Research26 Apr 2024
Nature Genetics

Volume: 56, P: 809-818
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

The innate sensors of SARS-CoV-2 are still being determined. Kanneganti and colleagues find that SARS-CoV-2 envelope protein is sensed by TLR2 and this drives pathogenic inflammatory cytokine production.

Min Zheng
Rajendra Karki
Thirumala-Devi Kanneganti
Research07 May 2021
Nature Immunology

Volume: 22, P: 829-838
Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease

Three covalent hybrid inhibitors of SARS-CoV-2 main protease (Mpro) have been designed and compared to Pfizer’s nirmatrelvir (PF-07321332), providing atomic and thermodynamic details of their binding to the enzyme, and antiviral potency.

Daniel W. Kneller
Hui Li
Andrey Kovalevsky
ResearchOpen Access27 Apr 2022
Nature Communications

Volume: 13, P: 1-11
Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2

The development of direct-acting antivirals to combat COVID-19 remains an important goal. Here the authors design covalent inhibitors that target the papain-like protease from SARS-CoV-2. The most promising inhibitor blocks viral replication in mammalian cells.

Brian C. Sanders
Suman Pokhrel
Jerry M. Parks
ResearchOpen Access28 Mar 2023
Nature Communications

Volume: 14, P: 1-17
The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells

Nicholas G. Nickols
Ekambaram Ganapathy
Dörthe Schaue
Research09 Jul 2020
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 135-139
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

The mechanisms by which Xist, a long non-coding RNA, silences one X chromosome in female mammals are unknown; here a mass spectrometry-based approach is developed to identify several proteins that interact directly with Xist, including the transcriptional repressor SHARP that is required for transcriptional silencing through the histone deacetylase HDAC3.

Colleen A. McHugh
Chun-Kan Chen
Mitchell Guttman
Research27 Apr 2015
Nature

Volume: 521, P: 232-236
Discovery and predictive modeling of urine microbiome, metabolite and cytokine biomarkers in hospitalized patients with community acquired pneumonia

Joseph F. Pierre
Oguz Akbilgic
Colleen B. Jonsson
ResearchOpen Access07 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Natural infection of Neotropical bats with hantavirus in Brazil

Gilberto Sabino-Santos Jr
Felipe Gonçalves Motta Maia
Luiz Tadeu Moraes Figueiredo
ResearchOpen Access13 Jun 2018
Scientific Reports

Volume: 8, P: 1-8
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project

David M S McHugh
Cynthia A Cameron
Wendy M Zakowicz
Research15 Feb 2011
Genetics in Medicine

Volume: 13, P: 230-254
Enhanced interpretation of newborn screening results without analyte cutoff values

Gregg Marquardt
Robert Currier
Gary L. Hoffman
Research16 Feb 2012
Genetics in Medicine

Volume: 14, P: 648-655

Search

A saturated map of common genetic variants associated with human height

Tegavivint triggers TECR-dependent nonapoptotic cancer cell death

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease

Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2

The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

Discovery and predictive modeling of urine microbiome, metabolite and cytokine biomarkers in hospitalized patients with community acquired pneumonia

Natural infection of Neotropical bats with hantavirus in Brazil

Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project

Enhanced interpretation of newborn screening results without analyte cutoff values

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