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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

γδ T cells have potent effector functions through their production of IFN-γ or IL-17. Pennington and colleagues demonstrate that IFN-γ⁺ γδ T and IL-17⁺ γδ T cells have distinct metabolic requirements that can be independently targeted to elicit specific immune responses.

Noella Lopes
Claire McIntyre
Lydia Lynch

Research18 Jan 2021

Nature Immunology

Volume: 22, P: 179-192

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Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction

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