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Towards credible digital twins for basic and preclinical research

Digital twins are well established in industrial settings, but there has not been wide adoption in biomedical settings. Digital twins for biomedical applications are now possible with the inclusion of artificial intelligence and the potential to combine mechanistic and clinical models that learn and adjust for human variability.

Colleen E. Clancy
Bennett A. Landman
Comments & Opinion08 Jan 2026
Nature Reviews Methods Primers

Volume: 6, P: 1-2
Wrapped around the heart

An elastic membrane cast around a three-dimensional printed model of a specific heart allows diverse aspects of cardiac function to be monitored and modified, and paves the way to new diagnostic and therapeutic approaches.

Colleen E. Clancy
Yang K. Xiang
News & Views05 Mar 2014
Nature

Volume: 507, P: 43-44
Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

Colleen E. Clancy
Yoram Rudy
Research05 Aug 1999
Nature

Volume: 400, P: 566-569
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome

Dieter Nuyens
Milan Stengl
Peter Carmeliet
Research01 Sept 2001
Nature Medicine

Volume: 7, P: 1021-1027
The formation of K_V2.1 macro-clusters is required for sex-specific differences in L-type Ca_V1.2 clustering and function in arterial myocytes

Advanced imaging and electrophysiology show that phosphorylation boosts the size of K_V2.1 clusters, which in turn modulates dihydropyridine-sensitive Ca_V1.2 channel organization and function in arterial smooth muscle, with variations based on sex.

Collin Matsumoto
Samantha C. O’Dwyer
L. Fernando Santana
ResearchOpen Access14 Nov 2023
Communications Biology

Volume: 6, P: 1-21
Mechanisms Restricting Diffusion of Intracellular cAMP

Shailesh R. Agarwal
Colleen E. Clancy
Robert D. Harvey
ResearchOpen Access22 Jan 2016
Scientific Reports

Volume: 6, P: 1-11

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Towards credible digital twins for basic and preclinical research

Wrapped around the heart

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome

The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes

Mechanisms Restricting Diffusion of Intracellular cAMP

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The formation of K_V2.1 macro-clusters is required for sex-specific differences in L-type Ca_V1.2 clustering and function in arterial myocytes