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Showing 1–5 of 5 results
Advanced filters: Author: Colleen M. Noviello Clear advanced filters

  • Cryo-electron microscopy structures of native type A GABA receptors from human brain reveal diverse subunit compositions, protein binding partners and binding sites for antiepileptic drugs.

    • Jia Zhou
    • Colleen M. Noviello
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 638, P: 562-568

  • The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor.

    • Shaotong Zhu
    • Colleen M. Noviello
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 559, P: 67-72

  • Cryo-electron microscopy structures of GABAA receptors bound to intravenous anaesthetics and benzodiazepines reveal both common and distinct transmembrane binding sites, and show that the mechanisms of action of anaesthetics partially overlap with those of benzodiazepines.

    • Jeong Joo Kim
    • Anant Gharpure
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 585, P: 303-308

  • Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a nicotinic receptor is reported, revealing how nicotine stabilizes the receptor in a non-conducting, desensitized conformation.

    • Claudio L. Morales-Perez
    • Colleen M. Noviello
    • Ryan E. Hibbs
    Research
    Nature
    Volume: 538, P: 411-415