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Showing 1–5 of 5 results
Advanced filters: Author: Colleen R. Reczek Clear advanced filters

  • This study highlights the role of mitochondrial complex I-dependent NAD+ regeneration in directing lung epithelial cell fate during postnatal alveolar development by preventing pathological integrated stress response induction.

    • SeungHye Han
    • Minho Lee
    • Navdeep S. Chandel
    ResearchOpen Access
    Nature
    Volume: 620, P: 890-897

  • How the mitochondrial electron transport chain (ETC) interacts with the NLRP3 inflammasome is somewhat unclear. Here the authors use individual complex inhibitors and new genetic models to show that ETC is critical in providing ATP via the phosphocreatine shuttle to activate the NLRP3 inflammasome.

    • Leah K. Billingham
    • Joshua S. Stoolman
    • Navdeep S. Chandel
    ResearchOpen Access
    Nature Immunology
    Volume: 23, P: 692-704

  • Oxidation of ubiquinol by the mitochondrial electron transfer chain drives tumour growth by maintaining the function of the oxidative Krebs cycle and de novo pyrimidine synthesis.

    • Inmaculada Martínez-Reyes
    • Luzivette Robles Cardona
    • Navdeep S. Chandel
    Research
    Nature
    Volume: 585, P: 288-292

  • A positive-selection CRISPR screen with the pro-oxidant paraquat (PQ) uncovers three genes mediating PQ-induced cell death: POR is the source of PQ-mediated reactive oxygen species (ROS) generation, and ATP7A and SLC45A4 promote oxidant-dependent cell death.

    • Colleen R Reczek
    • Kıvanç Birsoy
    • Navdeep S Chandel
    Research
    Nature Chemical Biology
    Volume: 13, P: 1274-1279