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Showing 1–2 of 2 results
Advanced filters: Author: Columba de la Parra Clear advanced filters

  • The differentiation of naive T cells to immune suppressing induced regulatory T (iTreg) cells requires TGF-beta-1 and downregulation of mTORC1 activity, which inhibits mRNA translation. Here the authors show that iTreg cell differentiation uses an alternate mRNA translation mechanism involving translation factors DAP5 and eIF3d.

    • Viviana Volta
    • Sandra Pérez-Baos
    • Robert J. Schneider
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Binding of eIF4E to the 5′ cap of mRNAs is a key early step in canonical translation initiation, but the requirement for eIF4E is not universal. Here the authors show that the eIF4G homolog DAP5 interacts with eIF3 to promote cap-dependent translation of a significant number of mRNA in an eIF4E-independent manner.

    • Columba de la Parra
    • Amanda Ernlund
    • Robert J. Schneider
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-9