The E3 ubiquitin ligase praja2 is expressed in glioblastoma (GBM), targets the kinase suppressor of Ras 2 for degradation and attenuates oxidative metabolism. Nanoparticle-mediated delivery of praja2 siRNA to GBM-bearing mice reduces tumour size.
- Rossella Delle Donne
- Rosa Iannucci
- Antonio Feliciello