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Na⁺-H⁺ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.

Cong-Lin Liu
Xian Zhang
Guo-Ping Shi
ResearchOpen Access04 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation

Interleukin-18 (IL18) has a pivotal role in interferon signalling and T cell development, but increasingly recognized as an adipokine that regulates energy metabolism in fat tissue. Authors here dissect the function of IL18 signalling in the adipose compartment by targeted genomic deletion of its two receptors individually and in combination in brown and white adipose tissues.

Xian Zhang
Songyuan Luo
Guo-Ping Shi
ResearchOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1-20
Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

This Review summarizes the growing body of evidence implicating cathepsin activities in the pathogenesis of several cardiovascular diseases, outlining the potential of cathepsins as biomarkers of disease progression and discussing clinical trials of cathepsin inhibitors in other diseases that highlight opportunities for developing novel therapies targeting cathepsins in cardiovascular diseases.

Cong-Lin Liu
Junli Guo
Guo-Ping Shi
Reviews20 Apr 2018
Nature Reviews Cardiology

Volume: 15, P: 351-370
Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis

Cong-Lin Liu
Marcela M. Santos
Guo-Ping Shi
ResearchOpen Access12 Apr 2017
Scientific Reports

Volume: 7, P: 1-12

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Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis

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Na⁺-H⁺ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis