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Target sequence-conditioned design of peptide binders using masked language modeling

PepMLM designs peptide binders against diverse targets using masked language modeling.

Leo Tianlai Chen
Zachary Quinn
Pranam Chatterjee
ResearchOpen Access13 Aug 2025
Nature Biotechnology

P: 1-9
SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders

SaLT&PepPr is a protein language model that isolates peptidic motifs from the binding interfaces of target-interacting partner sequences. These peptides are fused to an E3 ligase domain to generate peptide-guided protein degraders for diverse targets without structure.

Garyk Brixi
Tianzheng Ye
Pranam Chatterjee
ResearchOpen Access24 Oct 2023
Communications Biology

Volume: 6, P: 1-10

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Target sequence-conditioned design of peptide binders using masked language modeling

SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders

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