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Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

Being able to predict the therapeutic benefit of disease modifying anti-rheumatic drugs (DMARDs) would be of great benefit and a stepping stone towards personalized medicine. Here the authors use machine learning and lipid mediator mass spectrometry to show specialized pro-resolving mediators are indicative of DMARD responsiveness among rheumatoid arthritis patients.

Esteban A. Gomez
Romain A. Colas
Jesmond Dalli
ResearchOpen Access27 Oct 2020
Nature Communications

Volume: 11, P: 1-13
De novo derivation of proteomes from transcriptomes for transcript and protein identification

Integration of transcriptomic and proteomic data allows more detailed annotation of proteomes of model and non-model species.

Vanessa C Evans
Gary Barker
David A Matthews
Research11 Nov 2012
Nature Methods

Volume: 9, P: 1207-1211
Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

Improved methods to reconstruct global kinase-signaling networks from phosphoproteomics data are applied in cancer cells.

Maruan Hijazi
Ryan Smith
Pedro R. Cutillas
Research20 Jan 2020
Nature Biotechnology

Volume: 38, P: 493-502
Protein-folding location can regulate manganese-binding versus copper- or zinc-binding

This study identifies the most abundant Cu²⁺- and Mn²⁺-containing proteins in the periplasm of a cyanobacterium and determines that the cellular compartment in which each of those proteins fold is responsible for the insertion of the correct metal ion into the metalloprotein.

Steve Tottey
Kevin J. Waldron
Nigel J. Robinson
Research23 Oct 2008
Nature

Volume: 455, P: 1138-1142
Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

Emanuela Gadaleta
Pauline Fourgoux
Claude Chelala
ResearchOpen Access21 Aug 2020
npj Breast Cancer

Volume: 6, P: 1-12
Quantitative proteomic approach to study subcellular localization of membrane proteins

Pawel G Sadowski
Tom PJ Dunkley
Kathryn S Lilley
Protocols16 Nov 2006
Nature Protocols

Volume: 1, P: 1778-1789

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Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis

De novo derivation of proteomes from transcriptomes for transcript and protein identification

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

Protein-folding location can regulate manganese-binding versus copper- or zinc-binding

Characterization of four subtypes in morphologically normal tissue excised proximal and distal to breast cancer

Quantitative proteomic approach to study subcellular localization of membrane proteins

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